Thèse de doctorat : Université de Fribourg, 2000 ; no 1311.
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In: The Journal of Clinical Investigation, 2005, vol. 115(6), p. 1651
Thiazide diuretics enhance renal Na⁺ excretion by blocking the Na⁺-Cl⁻ cotransporter (NCC), and mutations in NCC result in Gitelman syndrome. The mechanisms underlying the accompanying hypocalciuria and hypomagnesemia remain debated. Here, we show that enhanced passive Ca²⁺ transport in the proximal tubule rather than active Ca²⁺ transport in distal convolution explains...
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Thèse de doctorat : Université de Fribourg, 2002 ; no 1372.
The goal of my Ph.D. thesis was to study the larval chemosensory system of the fruit fly Drosophila melanogaster, both in terms of its organization and neurotransmitter content. My studies were based on the enhancer trap technique, which provides useful neuronal marker lines and allows ectopic expression of any transgene of interest in the labeled cells. Four enhancer trap lines selected for...
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Thèse de doctorat : Université de Fribourg, 2001 ; no 1345.
Les Oomycètes sont de redoutables pathogènes pour les végétaux, particulièrement pour les plantes de culture et les pertes annuelles occasionnées par ces organismes sont considérables. Leur biologie est très différente de celle des champignons, même s’ils partagent avec ces derniers un mode de croissance mycélaire. Ainsi, il n’est pas aisé de les combattre et il n’existe que peu...
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Thèse de doctorat : Université de Fribourg, 2000 ; No 1304.
Phenotypic plasticity and genetic differentiation of the annual weed Senecio vulgaris L. from ruderal and agricultural habitats were investigated to evaluate the implications for its biological control with the rust fungus Puccinia lagenophorae Cooke using the system management approach. Weed demographic studies are a prerequisite to any weed control strategy. The population dynamics of S....
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Thèse de doctorat : Université de Fribourg, 2002 ; no 1386.
The secretory pathway is a complex endomembrane system essential for all eukaryotic cells. It transports proteins to the extracellular space or to the vacuole. All proteins which are secreted are synthesized at the endoplasmic reticulum (ER) and have a signal peptide in common. The signal peptide is necessary for the transport into the lumen of the ER where the correct folding of the protein...
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Thèse de doctorat : Université de Fribourg, 2002 ; No 1370.
In order to better understand the Phytophthora-plant interaction, we have developed a new pathosystem: Arabidopsis thaliana-Phytophthora porri. At present, the best studied Phytophthora species is P. infestans which caused the dramatic Irish late blight epidemics 150 years ago. Studying the pathosystem Phytophthora infestans-Solanum tuberosum has certain advantages mainly because potato is an...
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In: Tissue and Cell, 2004, vol. 36 (4), p. 245-248
Previous investigations of the T-system in skeletal muscle fibres described the inter-myofibrillar relationships between T-tubules and the sarcoplasmic reticulum. They disregarded the arrangement of the T-system in the myofibril-free sarcoplasm in the area of muscle fibre nuclei. In the present investigation, the T-system was filled by means of lanthanum incubation and the myofibril-free...
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Thèse de doctorat : Université de Fribourg : 2000 ; Nr. 1328.
Human gene therapy can be defined as the directed transfer of exogenous genes or other nucleotide sequences into somatic cells, for the purpose of preventing, correcting or healing various diseases. This novel approach to the therapy of human disorders is based on the realization that many previous medical treatments have usually been directed at the consequences of causative defects or at...
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Thèse de doctorat : Université de Fribourg : 2003 ; 1403.
La plupart des animaux, invertébrés inclus, ont la capacité de modifier leur comportement à la suite d'expériences, ils sont capables d'apprendre. Leur capacité d'apprentissage est elle-même un produit de l'évolution et le degré de modification d'un comportement par l'apprentissage varie selon les espèces et selon le comportement considéré. Pour un biologiste de l'évolution ceci...
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