In: Journal of Asian Earth sciences, 2006, no. 28, p. 457
|
In: Eukaryotic Cell, 2006, vol. 5, no. 7, p. 1018-1025
Steryl esters are stored in intracellular lipid droplets from which they are mobilized upon demand and hydrolyzed to yield free sterols and fatty acids. The mechanisms that control steryl ester mobilization are not well understood. We have previously identified a family of three lipases of Saccharomyces cerevisiae that are required for efficient steryl ester hydrolysis, Yeh1, Yeh2, and...
|
In: Biochemical Journal, 2007, vol. 401, no. 1, p. 205-216
Synthesis of VLCFAs (very long chain fatty acids) and biosynthesis of DHS (dihydrosphingosine) both are of vital importance for Saccharomyces cerevisiae. The bulk of VLCFAs and DHS are used for ceramide synthesis by the Lag1p (longevity-assurance gene 1)/Lac1p (longevity-assurance gene cognate 1)/Lip1p (Lag1p/Lac1p interacting protein) ceramide synthase. LAG1 and LAC1 are...
|
In: Journal of Biological Chemistry, 2012, p. -
Most ribosomal proteins play important roles in ribosome biogenesis and function. Herein, we have examined the contribution of the essential ribosomal protein L40 in these processes in the yeast Saccharomyces cerevisiae. Deletion of either the RPL40A or RPL40B gene and in vivo depletion of L40 impair 60S ribosomal subunit biogenesis. Polysome profile analyses reveal the accumulation of half-mers...
|
In: PLOS Genetics, 2017, vol. 13, no. 6, p. e1006835
The evolutionary conserved TOR complex 1 controls growth in response to the quality and quantity of nutrients such as carbon and amino acids. The protein kinase Sch9 is the main TORC1 effector in yeast. However, only few of its direct targets are known. In this study, we performed a genome-wide screening looking for mutants which require Sch9 function for their survival and growth. In this...
|
Thèse de doctorat : Université de Fribourg, 2006 ; no 1501.
Le cytomégalovirus est l’un des agents infectieux les plus communs chez les personnes immunodéficitaires, tels que les malades du SIDA ou les receveurs de greffe. Ce virus cause aussi fréquemment des infections congénitales. Les traitements existants sont limités par des défauts majeurs: mauvaise absorption, toxicité, efficacité restreinte à cause du développement de souches virales...
|
In: Cell Reports, 2012, vol. 3, no. 1, p. 16–22
The TORC1 and PKA protein kinases are central elements of signaling networks that regulate eukaryotic cell proliferation in response to growth factors and/or nutrients. In yeast, attenuation of signaling by these kinases following nitrogen and/or carbon limitation activates the protein kinase Rim15, which orchestrates the initiation of a reversible cellular quiescence program to ensure normal...
|
In: Biology Open, 2020, vol. 9, no. 6, p. bio053470
Members of the CAP/SCP/TAPS superfamily have been implicated in many different physiological processes, including pathogen defense, sperm maturation and fertilization. The mode of action of this class of proteins, however, remains poorly understood. The genome of Saccharomyces cerevisiae encodes three CAP superfamily members, Pry1-3. We have previously shown that Pry1 function is required...
|
In: Journal of Biological Chemistry, 2011, vol. 286, p. 6769-6779
In yeast, the inositolphosphorylceramides mostly contain C26:0 fatty acids. Inositolphosphorylceramides were considered to be important for viability because the inositolphosphorylceramide synthase AUR1 is essential. However, lcb1Δ cells, unable to make sphingoid bases and inositolphosphorylceramides, are viable if they harbor SLC1-1, a gain of function mutation in the...
|
In: Climatic Change, 2014, vol. 125, no. 3-4, p. 349-363
|
