In: Tissue and Cell, 2004, vol. 36 (4), p. 245-248
Previous investigations of the T-system in skeletal muscle fibres described the inter-myofibrillar relationships between T-tubules and the sarcoplasmic reticulum. They disregarded the arrangement of the T-system in the myofibril-free sarcoplasm in the area of muscle fibre nuclei. In the present investigation, the T-system was filled by means of lanthanum incubation and the myofibril-free...
|
Thèse de doctorat : Université de Fribourg, 2002 ; no 1395.
L'accroissement des fréquences et de l'impact de processus d'instabilités de terrain tels que des coulées de boue, laves torrentielles, glissements de terrain ou éboulements, au cours de la dernière décennie, a démontré la nécessité de mieux connaître les causes et la dynamique de ces processus. Ce travail de recherche s'inscrit dans une démarche visant à préciser les relations...
|
Thèse de doctorat : Université de Fribourg, 2002 ; no 1391.
La presente ricerca concerne lo studio dei prodotti ceramici provenienti dai due siti lacustri, del Neolitico finale, di Portalban e St. Blaise, in Svizzera occidentale, relativamente al gruppo culturale "Auvernier-cordé" (2700–2400 a.C.). Questi due importanti siti fanno parte della sequenza della Regione dei Tre Laghi (Neuchâtel, Bienne e Morat), la quale include la completa stratigrafia...
|
Thèse de doctorat : Université de Fribourg, 2001 ; Nr. 1361.
In eukaryotic cells, a subset of proteins is attached to the outer leaflet of the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. Apart from providing stable membrane anchorage, GPI anchors are thought to be associated with other functions, such as signal transduction and protein targeting. The biosynthesis of the GPI anchor and its transfer to proteins is highly conserved in...
|
Thèse de doctorat : Université de Fribourg, 2002 ; no 1398.
Suite aux découvertes successives faites par R. Kroto et H. Smalley [1] sur les fullerènes, du type C60 puis à celles de S. Iijima [2] sur les nanotubes de carbone (CNT), les chercheurs ont investi beaucoup de moyens afin de reproduire de telles formes allotropiques de carbone. Les différents procédés de synthèse mis en place durant les années 1990 ont permis d'obtenir des fullerènes du...
|
In: European Journal of Neuroscience, 2004, vol. 20, p. 2664-2670
Oxidative metabolism and cerebral blood flow (CBF) are two of the most important measures in neuroimaging. However, results from concurrent imaging of the two with high spatial and temporal resolution have never been published. We used flavoprotein autofluorescence (AF) and laser speckle imaging (LSI) in the anaesthetized rat to map oxidative metabolism and CBF in response to single vibrissa...
|
In: Physical Review Letters, 2004, vol. 93, p. 11570-11573
We show by means of experiments, theory, and simulations that the slow dynamics of coarsening systems displays dynamic heterogeneity similar to that observed in glass-forming systems. We measure dynamic heterogeneity via novel multipoint functions which quantify the emergence of dynamic, as opposed to static, correlations of fluctuations. Experiments are performed on a coarsening foam using...
|
Thèse de doctorat : Université de Fribourg : 2003 ; no 1400.
Proper chromosome segregation is a crucial event for accurate cell division. Defects in chromosome segregation lead to genetic instability and aneuploidy and are correlated with cancer. The laboratory studies chromosome segregation in the budding yeast Saccharomyces cerevisiae. Since this process is highly conserved among eukaryotes, studies in yeast will provide fundamental understanding of this...
|
Thèse de doctorat : Université de Fribourg : 2002 ; no 1388.
The biocompatibility of materials in implant or biosensor fields strongly depends on first interactions occurring between a given surface and a biological environment. It is well-known that a living body brought into contact with a surface will induce protein adsorption, which creates the interface, on which proteins or cells will adsorb. The interactions can be influenced by modifying the...
|
Thèse de doctorat : Université de Fribourg : 2000 ; Nr. 1328.
Human gene therapy can be defined as the directed transfer of exogenous genes or other nucleotide sequences into somatic cells, for the purpose of preventing, correcting or healing various diseases. This novel approach to the therapy of human disorders is based on the realization that many previous medical treatments have usually been directed at the consequences of causative defects or at...
|
