In: Cancer treatment reviews, 2020, vol. 90, p. 11
The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...
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In: Archives of Gynecology and Obstetrics, 2015, vol. 291, no. 6, p. 1387-1394
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In: Acta Neuropathologica, 2015, vol. 129, no. 5, p. 679-693
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In: Breast Cancer Research and Treatment, 2015, vol. 150, no. 2, p. 363-371
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In: Clinical & Experimental Metastasis, 2015, vol. 32, no. 7, p. 677-687
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In: Quality of Life Research, 2015, vol. 24, no. 9, p. 2151-2161
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In: Current Infectious Disease Reports, 2015, vol. 17, no. 4, p. 1-11
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In: SLEEP, 2016, vol. 40, no. 3, p. -
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In: Cell, 2016, vol. 166, no. 3, p. 596-608
Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when...
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In: Cell reports, 2020, vol. 32, no. 9, p. 12 p
Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize a multidonor antibody class (LPAF-a class) targeting the HA head. This class...
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