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GPI anchor attachment in yeast : analysis of Gpi8p, the putative catalytic subunit of the GPI: protein transamidase

Meyer, Urs ; Conzelmann, Andreas (Dir.) ; Puoti, Alessandro (Codir.)

Thèse de doctorat : Université de Fribourg, 2001 ; Nr. 1323.

Membrane anchoring of ceil surface proteins by means of glycosyl phosphatidyl-inositol (GPI) anchors is ubiquitous among eucaryotes. GPI anchoring is essential for yeast viability. In mammals, GPI anchoring is not required at the cellular level, but plays an important role in ceil to ceil and ceil to environment interactions which for example are critical during embryogenesis. GPI proteins can...