In: Oikos, 2005, vol. 110, no. 1, p. 55-66
Detailed studies on mammals and birds have shown that the effects of climate variation on population dynamics often depend on population composition, because weather affects different subsets of a population differently. It is presently unknown whether this is also true for ectothermic animals such as reptiles. Here we show such an interaction between weather and demography for an ectothermic...
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In: Integrative and Comparative Biology, 2006, vol. 46, no. 6, p. 655-661
Metamorphosis (Gr. meta- “change” + morphe “form”) as a biological process is generally attributed to a subset of animals: most famously insects and amphibians, but some fish and many marine invertebrates as well. We held a symposium at the 2006 Society for Integrative and Comparative Biology (SICB) annual meeting in Orlando, FL (USA) to discuss metamorphosis in a comparative context....
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In: Frontiers in Genetics, 2012, vol. 3, p. -
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In: Evolution, 2013, vol. 67, no. 12, p. 3573–3587
The major goal of evolutionary thermal biology is to understand how variation in temperature shapes phenotypic evolution. Comparing thermal reaction norms among populations from different thermal environments allows us to gain insights into the evolutionary mechanisms underlying thermal adaptation. Here, we have examined thermal adaptation in six wild populations of the fruit fly (Drosophila...
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In: npj Aging and Mechanisms of Disease, 2017, vol. 3, no. 1, p. 5
Mechanisms that ensure and maintain the stability of genetic information are fundamentally important for organismal function and can have a large impact on disease, aging, and life span. While a multi-layered cellular apparatus exists to detect and respond to DNA damage, various insults from environmental and endogenous sources continuously affect DNA integrity. Over time this can lead to the...
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In: BMC Genomics, 2010, vol. 11, no. 199, p. 1-19
Background: Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and inflammation. Mice lacking Tyk2 are resistant to endotoxin shock induced by lipopolysaccharide (LPS), and Tyk2 deficient macrophages fail to efficiently induce interferon alpha/beta after LPS treatment....
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In: Experimental Gerontology, 2011, vol. 46, no. 5, p. 369–375
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In: Science, 2007, vol. 318, p. 1255-1256
A theory of trade-offs to explain why we age has spurred 50 years of interdisciplinary research in evolution and molecular genetics.
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In: Experimental Gerontology, 2011, vol. 46, no. 2, p. 141–147
In the last two decades it has become clear that hormones and gene mutations in endocrine signaling pathways can exert major effects on lifespan and related life history traits in worms, flies, mice, and other organisms. While most of this research has focused on insulin/insulin-like growth factor-1 signaling, a peptide hormone pathway, recent work has shown that also lipophilic hormones play...
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In: Journal of Theoretical Biology, 2004, vol. 228(2), p. 241
Understanding the mechanisms that promote coexistence among species is a fundamental problem in evolutionary ecology. Such mechanisms include environmental noise, spatial population structure, density dependence, and genetic variation. In natural populations such factors may exert combined effects on coexistence. Thus, to disentangle the contribution of several factors to coexistence, their...
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