Université de Fribourg

The natural diyne-furan fatty acid EV-086 is an inhibitor of fungal delta-9 fatty acid desaturation with efficacy in a model of skin dermatophytosis

Knechtle, Philipp ; Diefenbacher, Melanie ; Greve, Katrine B. V. ; Brianza, Federico ; Folly, Christophe ; Heider, Harald ; Lone, Museer A. ; Long, Lisa ; Meyer, Jean-Philippe ; Roussel, Patrick ; Ghannoum, Mahmoud A. ; Schneiter, Roger ; Sorensen, Alexandra S.

In: Antimicrobial Agents and Chemotherapy, 2013, vol. 58, no. 1, p. 455–466

Human fungal infections represent a therapeutic challenge. Although effective strategies for treatment are available, resistance is spreading, and many therapies have unacceptable side effects. A clear need for novel antifungal targets and molecules is thus emerging. Here, we present the identification and characterization of the plant-derived diyne-furan fatty acid EV-086 as a novel antifungal...