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Crisis of emerging antibiotic resistances mirroring that of the COVID-19 in the age of globalisation

Nordmann, Patrice ; Poirel, Laurent ; Frey, Joachim

In: Swiss Medical Weekly, 2020, p. -

Derepressed transfer properties leading to the efficient spread of the plasmid encoding carbapenemase OXA-48

Potron, Anaïs ; Poirel, Laurent ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2013, vol. 58, no. 1, p. 467–471

The current emergence of the carbapenemase OXA-48 among Enterobacteriaceae is related to the spread of a single IncL/M-type plasmid, pOXA-48a. This plasmid harbors the blaOXA-48 gene within a composite transposon, Tn1999, which is inserted into the tir gene, encoding a transfer inhibition protein. We showed that the insertion of Tn1999 into the...

Dissemination of carbapenemase-producing Enterobacteriaceae in France, 2012

Dortet, Laurent ; Cuzon, Gaelle ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2014, vol. 69, no. 3, p. 623-627

Dissemination of carbapenemase-producing Enterobacteriaceae in France, 2012

Dortet, Laurent ; Cuzon, Gaelle ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2014, vol. 69, no. 3, p. 623-627

Objectives: Carbapenem-resistant Enterobacteriaceae isolates (n = 1485) were received at the French Associated National Reference Center for Antibiotic Resistance in 2012 and were characterized for their mechanism of resistance to carbapenems.Methods: Carbapenemase production was detected using the biochemical-based Carba NP test, based on the detection of in vitro hydrolysis of imipenem. All...

Efficacy of Humanized Carbapenem and Ceftazidime Regimens against Enterobacteriaceae Producing OXA-48 Carbapenemase in a Murine Infection Model

Wiskirchen, Dora E. ; Nordmann, Patrice ; Crandon, Jared L. ; Nicolau, David P.

In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, no. 3, p. 1678–1683

Enterobacteriaceae producing the OXA-48 carbapenemase are emerging worldwide, leaving few treatment options. Efficacy has been demonstrated in vivo with ceftazidime against a ceftazidime-susceptible OXA-48 isolate but not with imipenem despite maintaining susceptibility. The relationship between phenotype and in vivo efficacy was assessed for OXA-48 producers using humanized regimens of 2 g...

Emergence of an MDR Klebsiella pneumoniae ST231 producing OXA-232 and RmtF in Switzerland

Mancini, Stefano ; Poirel, Laurent ; Tritten, Marie-Lise ; Lienhard, Reto ; Bassi, Cécile ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2018, vol. 73, no. 3, p. 821-823

Emergence of colistin resistance in Klebsiella pneumoniae from veterinary medicine

Kieffer, Nicolas ; Poirel, Laurent ; Nordmann, Patrice ; Madec, Jean-Yves ; Haenni, Marisa

In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 4, p. 1265-1267

Emergence of OXA-72-producing Acinetobacter pittii clinical isolates

Bonnin, Rémy A. ; Docobo-Pérez, Fernando ; Poirel, Laurent ; Villegas, Maria-Virginia ; Nordmann, Patrice

In: International Journal of Antimicrobial Agents, 2014, vol. 43, no. 2, p. 195–196

Emergence of the 16S rRNA methylase RmtG in an extended-spectrum-β-lactamase-producing and colistin-resistant Klebsiella pneumoniae isolate in Chile

Poirel, Laurent ; Labarca, Jaime ; Bello, Helia ; Rioseco, Maria Luisa ; Bernabeu, Sandrine ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, no. 1, p. 618–619

Emerging plasmid-encoded colistin resistance: the animal world as the culprit?

Poirel, Laurent ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2016, vol. 71, no. 8, p. 2326-2327