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Impact of the isolation medium for detection of carbapenemase-producing Enterobacteriaceae using an updated version of the Carba NP test

Dortet, Laurent ; Bréchard, Ludivine ; Poirel, Laurent ; Nordmann, Patrice

In: Journal of Medical Microbiology, 2014, vol. 63, no. Pt_5, p. 772–776

Strategy for a rapid detection of carbapenemase-producing Enterobacteriaceae

Dortet, Laurent ; Bréchard, Ludivine ; Cuzon, Gaëlle ; Poirel, Laurent ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, no. 4, p. 2441-2445

A prospective survey was conducted on 862 Enterobacteriaceae with reduced susceptibility to carbapenems. The Carba NP test, UV spectrophotometry and DNA microarray were used for detecting carbapenemase producers, and results compared to PCR and sequencing. The 172 carbapenemase producers were detected using the Carba NP test and UV spectrophotometry whereas DNA microarray failed to detect IMI...

Rapid detection of carbapenemase-producing Enterobacteriaceae from blood cultures

Dortet, Laurent ; Bréchard, Ludivine ; Poirel, Laurent ; Nordmann, Patrice

In: Clinical Microbiology and Infection, 2013, p. -

The biochemical-based Carba NP test has been evaluated to detect carbapenemase- producing Enterobacteriaceae (n = 193) directly from spiked blood cultures. It was able to rapidly detect KPC (n = 50), IMP (n = 27), VIM (n = 37), NDM (n = 33) and OXA-48-like producers (n = 46) with sensitivity and specificity of 97.9% and 100%, respectively. This cost-effective technique may be implemented in...