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    Université de Fribourg

    Nuclear translocation of components of the neuronal plasma membrane oxidoreductase after oxidative stress and its effects on induction of apoptosis

    Dastoor, Zubin ; Dreyer, Jean-Luc (Dir.) ; Conzelmann, Andreas (Codir.) ; Clarke, Peter G.H. (Codir.)

    Thèse de doctorat : Université de Fribourg, 2000 ; Nr, 1293.

    The plasma membrane oxidoreductase (PMO) complex may exert important functions in cellular defence mechanism against oxidative stress and in apoptosis. Thus, we aimed to investigate the function of the five proteins GAPDH, Hsc70, enolase γ, aldolase C and Ulip, all of them tightly bound members of a neuronal PMO multi-protein complex, previously isolated and purified from synaptic vesicles and...

    Université de Fribourg

    Hematopoietic regulation by catecholamines

    Togni, Mauro ; Dreyer, Jean-Luc (Dir.)

    Thèse de doctorat : Université de Fribourg, 2000 ; no 1284.

    Université de Fribourg

    Identification of genes differentially expressed upon cocaine treatment and of new rat semaphorins

    Brenz Verca-Kouznetsova, Maria ; Dreyer, Jean-Luc (Dir.)

    Thèse de doctorat : Université de Fribourg : 2000 ; no 1329.

    At the behavioral level drug addiction is defined as compulsion to take a drug with loss of control over apparently voluntary acts of drug seeking and drug taking. At the neuronal level drugs elicit two types of responses: neuronal adaptations, i.e. homeostatic responses to excessive stimulation, and synaptic plasticity. At the molecular level both processes are paralleled by changes in gene...