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Perfect timing: epigenetic regulation of the circadian clock

Ripperger, Jürgen A. ; Merrow, Martha

In: FEBS Letters, 2011, p. -

In mammals, higher order chromatin structures are critical for downsizing the genome (packaging) so that the nucleus can be small. The adjustable density of chromatin also regulates gene expression, thus this post-genetic molecular mechanism is one of the routes by which phenotype is shaped. Phenotypes that arise without a concomitant mutation of the underlying genome are termed epigenetic...