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Postnatal development of metabolic flexibility and enhanced oxidative capacity after prenatal undernutrition

Norman, Amy M. ; Miles-Chan, Jennifer L. ; Thompson, Nichola M. ; Breier, Bernhard H. ; Huber, Korinna

In: Reproductive Sciences, 2012, vol. 19, no. 6, p. 607-614

Metabolic flexibility is the body’s ability to adapt to changing energy demand and nutrient supply. Maternal undernutrition causes growth restriction at birth and subsequent obesity development. Intriguingly, metabolic flexibility is maintained due to adaptations of muscle tissue. The aim of the present study was to investigate developmental pathways of these adaptive changes. Wistar rats...