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MR-based attenuation correction for cardiac FDG PET on a hybrid PET/MRI scanner: comparison with standard CT attenuation correction

Vontobel, Jan ; Liga, Riccardo ; Possner, Mathias ; Clerc, Olivier ; Mikulicic, Fran ; Veit-Haibach, Patrick ; ter Voert, Edwin ; Fuchs, Tobias ; Stehli, Julia ; Pazhenkottil, Aju ; Benz, Dominik ; Gräni, Christoph ; Gaemperli, Oliver ; Herzog, Bernhard ; Buechel, Ronny ; Kaufmann, Philipp

In: European Journal of Nuclear Medicine and Molecular Imaging, 2015, vol. 42, no. 10, p. 1574-1580

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    Title
    • MR-based attenuation correction for cardiac FDG PET on a hybrid PET/MRI scanner: comparison with standard CT attenuation correction
    Author
    • Vontobel, Jan. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Liga, Riccardo. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Possner, Mathias. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Clerc, Olivier. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Mikulicic, Fran. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Veit-Haibach, Patrick. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • ter Voert, Edwin. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Fuchs, Tobias. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Stehli, Julia. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Pazhenkottil, Aju. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Benz, Dominik. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Gräni, Christoph. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Gaemperli, Oliver. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Herzog, Bernhard. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Buechel, Ronny. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Kaufmann, Philipp. Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • European Journal of Nuclear Medicine and Molecular Imaging, 2015, vol. 42, no. 10, p. 1574-1580. Springer Berlin Heidelberg
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:332935
    Summary
    Purpose: The aim of this study was to evaluate the feasibility of attenuation correction (AC) for cardiac 18F-labelled fluorodeoxyglucose (FDG) positron emission tomography (PET) using MR-based attenuation maps. Methods: We included 23 patients with no known cardiac history undergoing whole-body FDG PET/CT imaging for oncological indications on a PET/CT scanner using time-of-flight (TOF) and subsequent whole-body PET/MR imaging on an investigational hybrid PET/MRI scanner. Data sets from PET/MRI (with and without TOF) were reconstructed using MR AC and semi-quantitative segmental (20-segment model) myocardial tracer uptake (per cent of maximum) and compared to PET/CT which was reconstructed using CT AC and served as standard of reference. Results: Excellent correlations were found for regional uptake values between PET/CT and PET/MRI with TOF (n = 460 segments in 23 patients; r = 0.913; p < 0.0001) with narrow Bland-Altman limits of agreement (−8.5 to +12.6%). Correlation coefficients were slightly lower between PET/CT and PET/MRI without TOF (n = 460 segments in 23 patients; r = 0.851; p < 0.0001) with broader Bland-Altman limits of agreement (−12.5 to +15.0%). PET/MRI with and without TOF showed minimal underestimation of tracer uptake (−2.08 and −1.29%, respectively), compared to PET/CT. Conclusion: Relative myocardial FDG uptake obtained from MR-based attenuation corrected FDG PET is highly comparable to standard CT-based attenuation corrected FDG PET, suggesting interchangeability of both AC techniques.