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Increased periodontal inflammation in women with preterm premature rupture of membranes

Stadelmann, Pascale ; Eick, Sigrun ; Salvi, Giovanni ; Surbek, Daniel ; Mohr, Stefan ; Bürgin, Walter ; Ramseier, Christoph ; Sculean, Anton

In: Clinical Oral Investigations, 2015, vol. 19, no. 6, p. 1537-1546

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    Titel
    • Increased periodontal inflammation in women with preterm premature rupture of membranes
    Autor
    • Stadelmann, Pascale. Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland
    • Eick, Sigrun. Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland
    • Salvi, Giovanni. Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland
    • Surbek, Daniel. Department of Obstetrics and Gynecology, University Hospital Bern and University of Bern, Bern, Switzerland
    • Mohr, Stefan. Department of Obstetrics and Gynecology, University Hospital Bern and University of Bern, Bern, Switzerland
    • Bürgin, Walter. Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland
    • Ramseier, Christoph. Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland
    • Sculean, Anton. Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Clinical Oral Investigations, 2015, vol. 19, no. 6, p. 1537-1546. Springer Berlin Heidelberg
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:332897
    Summary
    Objectives: To evaluate possible differences in periodontal inflammatory, microbiological and clinical parameters between women with preterm premature rupture of membranes (PPROM) and controls with uncomplicated pregnancies. Materials and methods: Fifty-six women (32 test (PPROM) and 24 controls (uncomplicated pregnancies)) were examined at three time-points (T1: gestational weeks 20-35, T2: within 48h after parturition, T3: 4-6weeks after parturition). The examinations included assessment of the Periodontal Screening Index, collection of gingival crevicular fluid (GCF) and subgingival as well as vaginal bacterial sampling. Results: Periodontal inflammation was found to be higher in the test compared with the control group (p < 0.05) and decreased over time in both groups (p < 0.05). Microbiological outcomes showed no intergroup differences (p > 0.05) in prevalence of bacteria, but a decrease in subgingival periodontopathogens from T1 to T2 in the test group (p < 0.05) was observed. Interleukin (IL)-1β levels in GCF at T2 were not different between groups (p > 0.05). In women with PPROM, GCF levels of IL-8 (p < 0.05) and C-reactive protein (p < 0.05) were lower and IL-10 levels higher (p < 0.05) compared with controls. Conclusions: Periodontal inflammation is elevated during pregnancy and seems to be more pronounced in women with PPROM. Clinical relevance: The findings of the present study revealed an association between periodontal inflammation and PPROM, thus emphasizing the importance of optimizing self-performed oral hygiene in pregnant women.