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Shared neural basis of social and non-social reward deficits in chronic cocaine users

Tobler, Philippe N. ; Preller, Katrin H. ; Campbell-Meiklejohn, Daniel K. ; Kirschner, Matthias ; Kraehenmann, Rainer ; Stämpfli, Philipp ; Herdener, Marcus ; Seifritz, Erich ; Quednow, Boris B.

In: Social Cognitive and Affective Neuroscience, 2016, vol. 11, no. 6, p. 1017-1025

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    Titre
    • Shared neural basis of social and non-social reward deficits in chronic cocaine users
    Auteur
    • Tobler, Philippe N.. Department of Economics, University of Zurich, 8006 Zurich, Switzerland
    • Preller, Katrin H.. Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Psychiatric Hospital, 8032 Zurich, Switzerland
    • Campbell-Meiklejohn, Daniel K.. School of Psychology, University of Sussex, Falmer BN1 9QH UK
    • Kirschner, Matthias. Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Psychiatric Hospital, 8032 Zurich, Switzerland
    • Kraehenmann, Rainer. Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Psychiatric Hospital, 8032 Zurich, Switzerland
    • Stämpfli, Philipp. Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Psychiatric Hospital, 8032 Zurich, Switzerland
    • Herdener, Marcus. Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Psychiatric Hospital, 8032 Zurich, Switzerland
    • Seifritz, Erich. Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, 8057 Zurich, Switzerland
    • Quednow, Boris B.. Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, 8057 Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Social Cognitive and Affective Neuroscience, 2016, vol. 11, no. 6, p. 1017-1025. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332808
    Summary
    Changed reward functions have been proposed as a core feature of stimulant addiction, typically observed as reduced neural responses to non-drug-related rewards. However, it was unclear yet how specific this deficit is for different types of non-drug rewards arising from social and non-social reinforcements. We used functional neuroimaging in cocaine users to investigate explicit social reward as modeled by agreement of music preferences with music experts. In addition, we investigated non-social reward as modeled by winning desired music pieces. The study included 17 chronic cocaine users and 17 matched stimulant-naive healthy controls. Cocaine users, compared with controls, showed blunted neural responses to both social and non-social reward. Activation differences were located in the ventromedial prefrontal cortex overlapping for both reward types and, thus, suggesting a non-specific deficit in the processing of non-drug rewards. Interestingly, in the posterior lateral orbitofrontal cortex, social reward responses of cocaine users decreased with the degree to which they were influenced by social feedback from the experts, a response pattern that was opposite to that observed in healthy controls. The present results suggest that cocaine users likely suffer from a generalized impairment in value representation as well as from an aberrant processing of social feedback.