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Regional Radiation Pneumonitis After SIRT of a Subcapsular Liver Metastasis: What is the Effect of Direct Beta Irradiation?

Dobrocky, Tomas ; Fuerstner, Markus ; Klaeser, Bernd ; Lopez-Benitez, Ruben ; Wälti, Yara ; Kara, Levent

In: CardioVascular and Interventional Radiology, 2015, vol. 38, no. 4, p. 1025-1030

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    Titre
    • Regional Radiation Pneumonitis After SIRT of a Subcapsular Liver Metastasis: What is the Effect of Direct Beta Irradiation?
    Auteur
    • Dobrocky, Tomas. Department of Interventional, Pediatric and Diagnostic Radiology, Inselspital, University Hospital, University of Bern, Freiburgstrasse 10, 3010, Bern, Switzerland
    • Fuerstner, Markus. Department of Nuclear Medicine, Inselspital, University Hospital, University of Bern, Freiburgstrasse 10, 3010, Bern, Switzerland
    • Klaeser, Bernd. Department of Nuclear Medicine, Inselspital, University Hospital, University of Bern, Freiburgstrasse 10, 3010, Bern, Switzerland
    • Lopez-Benitez, Ruben. Department of Interventional, Pediatric and Diagnostic Radiology, Inselspital, University Hospital, University of Bern, Freiburgstrasse 10, 3010, Bern, Switzerland
    • Wälti, Yara. Institute of Pathology, University Hospital, University of Bern, Freiburgstrasse 10, 3010, Bern, Switzerland
    • Kara, Levent. Department of Interventional, Pediatric and Diagnostic Radiology, Inselspital, University Hospital, University of Bern, Freiburgstrasse 10, 3010, Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • CardioVascular and Interventional Radiology, 2015, vol. 38, no. 4, p. 1025-1030. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332546
    Summary
    We herein present a patient undergoing selective internal radiation therapy with an almost normal lung shunt fraction of 11.5%, developing histologically proven radiation pneumonitis. Due to a predominance of pulmonary consolidations in the right lower lung and its proximity to a large liver metastases located in the dome of the right liver lobe a Monte Carlo simulation was performed to estimate the effect of direct irradiation of the lung parenchyma. According to our calculations direct irradiation seems negligible and RP is almost exclusively due to ectopic draining of radioactive spheres.