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Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs

Buset, Sabrina ; Zitzmann, Nicola ; Weiger, Roland ; Walter, Clemens

In: Clinical Oral Investigations, 2015, vol. 19, no. 8, p. 1763-1775

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    Titre
    • Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs
    Auteur
    • Buset, Sabrina. Department of Periodontology, Endodontology and Cariology, University of Basel, Hebelstrasse 3, CH-4056, Basel, Switzerland
    • Zitzmann, Nicola. Department of Periodontology, Endodontology and Cariology, University of Basel, Hebelstrasse 3, CH-4056, Basel, Switzerland
    • Weiger, Roland. Department of Periodontology, Endodontology and Cariology, University of Basel, Hebelstrasse 3, CH-4056, Basel, Switzerland
    • Walter, Clemens. Department of Periodontology, Endodontology and Cariology, University of Basel, Hebelstrasse 3, CH-4056, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Clinical Oral Investigations, 2015, vol. 19, no. 8, p. 1763-1775. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332544
    Summary
    Background: Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy. Objective: This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically administered azithromycin. Materials and methods: A systematic literature search was performed for publications published by 31 March 2014 using electronic databases and hand search. Randomized controlled trials published in English or German language, with a follow-up ≥6months were included. From 231 titles identified, nine publications were eligible for inclusion. Results: Among the studies included, showing some risk of bias, seven reported on patients with chronic periodontitis and two with aggressive periodontitis. Minor adverse events were described in five studies. A synthesis of results using a vote counting method was applied. Significant (p < 0.05) beneficial effects of azithromycin were shown in six studies for probing depth changes and in five studies for clinical attachment level changes. Conclusion: In contrast to aggressive periodontitis patients, data from this analysis indicate a potential benefit of systemic azithromycin as adjunctive to non-surgical periodontal therapy in chronic periodontitis patients. Clinical relevance: When contraindications for the standard antibiotics are present, azithromycin (AZM) may be considered as alternative systemically administered antibiotic drug in selected cases of chronic periodontitis.