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Mistaking 2C-P for 2C-B: What a Difference a Letter Makes

Stoller, Adrian ; Dolder, Patrick C. ; Bodmer, Michael ; Hammann, Felix ; Rentsch, Katharina M. ; Exadaktylos, Aristomenis K. ; Liechti, Matthias E. ; Liakoni, Evangelia

In: Journal of Analytical Toxicology, 2017, vol. 41, no. 1, p. 77-79

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    Titel
    • Mistaking 2C-P for 2C-B: What a Difference a Letter Makes
    Autor
    • Stoller, Adrian. Department of Nephrology, Hypertension and Clinical Pharmacology, Inselspital, Bern University Hospital, University of Bern, Switzerland
    • Dolder, Patrick C.. Division of Clinical Pharmacology and Toxicology
    • Bodmer, Michael. Emergency Department, Inselspital, Bern University Hospital, University of Bern, Switzerland
    • Hammann, Felix. Division of Clinical Pharmacology and Toxicology
    • Rentsch, Katharina M.. Laboratory Medicine, University Hospital Basel and University of Basel, Switzerland
    • Exadaktylos, Aristomenis K.. Emergency Department, Inselspital, Bern University Hospital, University of Bern, Switzerland
    • Liechti, Matthias E.. Division of Clinical Pharmacology and Toxicology
    • Liakoni, Evangelia. Department of Nephrology, Hypertension and Clinical Pharmacology, Inselspital, Bern University Hospital, University of Bern, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Journal of Analytical Toxicology, 2017, vol. 41, no. 1, p. 77-79. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:332495
    Summary
    2,5-Dimethoxy-4(n)-propylphenethylamine (2C-P) is a synthetic phenethylamine derivative belonging to the large family of the so-called 2C drugs. These compounds can differ significantly in receptor affinity, potency and duration of action, and an important structural difference is the ligand in the 4 position of the phenyl ring, such as propyl in 2C-P or bromine in 2,5-dimethoxy-4-bromophenethylamine (2C-B). The 2C drugs are known for their hallucinogenic properties. We present a case of a 19-year-old male admitted to the emergency department with severe hallucinations, mydriasis, tachycardia, agitation and confusion following the use of a substance sold as 2C-B. By using liquid chromatography-mass spectrometry, the more potent substance 2C-P was detected and quantified. On the basis of two blood sample concentrations, the estimated elimination half-life was 19 h. This case report illustrates and discusses the differences in potency and duration of action of 2C drugs.