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Acoustophoretic cell and particle trapping on microfluidic sharp edges

Leibacher, Ivo ; Hahn, Philipp ; Dual, Jürg

In: Microfluidics and Nanofluidics, 2015, vol. 19, no. 4, p. 923-933

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    Titre
    • Acoustophoretic cell and particle trapping on microfluidic sharp edges
    Auteur
    • Leibacher, Ivo. Department of Mechanical and Process Engineering, Institute of Mechanical Systems (IMES), Swiss Federal Institute of Technology (ETH Zurich), Tannenstrasse 3, 8092, Zurich, Switzerland
    • Hahn, Philipp. Department of Mechanical and Process Engineering, Institute of Mechanical Systems (IMES), Swiss Federal Institute of Technology (ETH Zurich), Tannenstrasse 3, 8092, Zurich, Switzerland
    • Dual, Jürg. Department of Mechanical and Process Engineering, Institute of Mechanical Systems (IMES), Swiss Federal Institute of Technology (ETH Zurich), Tannenstrasse 3, 8092, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Microfluidics and Nanofluidics, 2015, vol. 19, no. 4, p. 923-933. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332482
    Summary
    Cell and particle trapping experience a rising interest in a microfluidic context. Trapping of cells in suspension at distinct locations in a microfluidic domain is relevant for cell biological lab-on-a-chip systems, where a trap provides a well-definable microenvironment for cell response studies. This paper reports a novel acoustophoretic cell trapping effect on oscillating sharp edge structures which protrude into a microfluidic channel. These edge structures (125-250 $$\upmu \hbox {m}$$ μ m length, 10-80 $$\upmu \hbox {m}$$ μ m width in the experiments) were found to attract cells and particles strongly and reliably upon simple piezoelectric excitation around 1MHz. The method is contact- and label-free, robust, and biocompatible. The physical trapping effect is experimentally characterized, and a numerical model is proposed, based on the theory of acoustic radiation forces.