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Multicontact Co-operativity in Spike-Timing-Dependent Structural Plasticity Stabilizes Networks

Deger, Moritz ; Seeholzer, Alexander ; Gerstner, Wulfram

In: Cerebral Cortex, 2018, vol. 28, no. 4, p. 1396-1415

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    Titre
    • Multicontact Co-operativity in Spike-Timing-Dependent Structural Plasticity Stabilizes Networks
    Auteur
    • Deger, Moritz. School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne EPFL, Switzerland
    • Seeholzer, Alexander. School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne EPFL, Switzerland
    • Gerstner, Wulfram. School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne EPFL, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cerebral Cortex, 2018, vol. 28, no. 4, p. 1396-1415. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332388
    Summary
    Excitatory synaptic connections in the adult neocortex consist of multiple synaptic contacts, almost exclusively formed on dendritic spines. Changes of spine volume, a correlate of synaptic strength, can be tracked in vivo for weeks. Here, we present a combined model of structural and spike-timing-dependent plasticity that explains the multicontact configuration of synapses in adult neocortical networks under steady-state and lesion-induced conditions. Our plasticity rule with Hebbian and anti-Hebbian terms stabilizes both the postsynaptic firing rate and correlations between the pre- and postsynaptic activity at an active synaptic contact. Contacts appear spontaneously at a low rate and disappear if their strength approaches zero. Many presynaptic neurons compete to make strong synaptic connections onto a postsynaptic neuron, whereas the synaptic contacts of a given presynaptic neuron co-operate via postsynaptic firing. We find that co-operation of multiple synaptic contacts is crucial for stable, long-term synaptic memories. In simulations of a simplified network model of barrel cortex, our plasticity rule reproduces whisker-trimming-induced rewiring of thalamocortical and recurrent synaptic connectivity on realistic time scales.