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Further reductions in nonvertebral fracture rate with long-term denosumab treatment in the FREEDOM open-label extension and influence of hip bone mineral density after 3years

Ferrari, S. ; Adachi, J. ; Lippuner, K. ; Zapalowski, C. ; Miller, P. ; Reginster, J.-Y ; Törring, O. ; Kendler, D. ; Daizadeh, N. ; Wang, A. ; O'Malley, C. ; Wagman, R. ; Libanati, C. ; Lewiecki, E.

In: Osteoporosis International, 2015, vol. 26, no. 12, p. 2763-2771

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    Titre
    • Further reductions in nonvertebral fracture rate with long-term denosumab treatment in the FREEDOM open-label extension and influence of hip bone mineral density after 3years
    Auteur
    • Ferrari, S.. Geneva University Hospital, Geneva, Switzerland
    • Adachi, J.. McMaster University, Hamilton, ON, Canada
    • Lippuner, K.. Bern University Hospital, Bern, Switzerland
    • Zapalowski, C.. Amgen Inc., Thousand Oaks, CA, USA
    • Miller, P.. Colorado Center for Bone Research, Lakewood, CO, USA
    • Reginster, J.-Y. University of Liège, Liège, Belgium
    • Törring, O.. Karolinska Institutet, Södersjukhuset, Stockholm, Sweden
    • Kendler, D.. University of British Columbia, Vancouver, BC, Canada
    • Daizadeh, N.. Amgen Inc., Thousand Oaks, CA, USA
    • Wang, A.. Amgen Inc., Thousand Oaks, CA, USA
    • O'Malley, C.. Amgen Inc., Thousand Oaks, CA, USA
    • Wagman, R.. Amgen Inc., Thousand Oaks, CA, USA
    • Libanati, C.. Amgen Inc., Thousand Oaks, CA, USA
    • Lewiecki, E.. New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, USA
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Osteoporosis International, 2015, vol. 26, no. 12, p. 2763-2771. Springer London
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332374
    Summary
    Summary: Limited data exist on the efficacy of long-term therapies for osteoporosis. In osteoporotic postmenopausal women receiving denosumab for 7years, nonvertebral fracture rates significantly decreased in years 4-7 versus years 1-3. This is the first demonstration of a further benefit on fracture outcomes with long-term therapy for osteoporosis. Introduction: This study aimed to evaluate whether denosumab treatment continued beyond 3years is associated with a further reduction in nonvertebral fracture rates. Methods: Participants who completed the 3-year placebo-controlled Fracture REduction Evaluation of Denosumab in Osteoporosis every 6 Months (FREEDOM) study were invited to participate in an open-label extension. The present analysis includes 4,074 postmenopausal women with osteoporosis (n = 2,343 long-term; n = 1,731 cross-over) who enrolled in the extension, missed ≤1 dose during their first 3years of denosumab treatment, and continued into the fourth year of treatment. Comparison of nonvertebral fracture rates during years 1-3 of denosumab with that of the fourth year and with the rate during years 4-7 was evaluated. Results: For the combined group, the nonvertebral fracture rate per 100 participant-years was 2.15 for the first 3years of denosumab treatment (referent) and 1.36 in the fourth year (rate ratio [RR] = 0.64; 95% confidence interval (CI) = 0.48 to 0.85, p = 0.003). Comparable findings were observed in the groups separately and when nonvertebral fracture rates during years 1-3 were compared to years 4-7 in the long-term group (RR = 0.79; 95% CI = 0.62 to 1.00, p = 0.046). Fracture rate reductions in year 4 were most prominent in subjects with persisting low hip bone mineral density (BMD). Conclusions: Denosumab treatment beyond 3years was associated with a further reduction in nonvertebral fracture rate that persisted through 7years of continuous denosumab administration. The degree to which denosumab further reduces nonvertebral fracture risk appears influenced by the hip bone density achieved with initial therapy.