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A three-dimensional in vitro dynamic micro-tissue model of cardiac scar formation

Occhetta, Paola ; Isu, Giuseppe ; Lemme, Marta ; Conficconi, Chiara ; Oertle, Philipp ; Räz, Christian ; Visone, Roberta ; Cerino, Giulia ; Plodinec, Marija ; Rasponi, Marco ; Marsano, Anna

In: Integrative Biology, 2018, vol. 10, no. 3, p. 174-183

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    Titre
    • A three-dimensional in vitro dynamic micro-tissue model of cardiac scar formation
    Auteur
    • Occhetta, Paola. Department of Biomedicine, University of Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Tel: +41 (0)61 265 2979
    • Isu, Giuseppe. Department of Biomedicine, University of Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Tel: +41 (0)61 265 2979
    • Lemme, Marta. Department of Biomedicine, University of Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Tel: +41 (0)61 265 2979
    • Conficconi, Chiara. Department of Biomedicine, University of Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Tel: +41 (0)61 265 2979
    • Oertle, Philipp. Biozentrum and the Swiss Nanoscience Institute, University of Basel, 4056 Basel, Switzerland
    • Räz, Christian. Biozentrum and the Swiss Nanoscience Institute, University of Basel, 4056 Basel, Switzerland
    • Visone, Roberta. Department of Electronics, Information and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, Building #21, 20133 Milano, Italy
    • Cerino, Giulia. Department of Biomedicine, University of Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Tel: +41 (0)61 265 2979
    • Plodinec, Marija. Biozentrum and the Swiss Nanoscience Institute, University of Basel, 4056 Basel, Switzerland
    • Rasponi, Marco. Department of Electronics, Information and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, Building #21, 20133 Milano, Italy
    • Marsano, Anna. Department of Biomedicine, University of Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Tel: +41 (0)61 265 2979
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Integrative Biology, 2018, vol. 10, no. 3, p. 174-183. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332336
    Summary
    Our 3D-scar-on-a-chip model resembles fibroblast proliferation and activation, extracellular matrix deposition and stiffening upon application of only cyclic mechanical stretching.