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Fluoride varnishes containing calcium glycerophosphate: fluoride uptake and the effect on in vitro enamel erosion

Carvalho, Thiago ; Bönecker, Marcelo ; Altenburger, Markus ; Buzalaf, Marília ; Sampaio, Fabio ; Lussi, Adrian

In: Clinical Oral Investigations, 2015, vol. 19, no. 6, p. 1429-1436

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    Title
    • Fluoride varnishes containing calcium glycerophosphate: fluoride uptake and the effect on in vitro enamel erosion
    Author
    • Carvalho, Thiago. Department of Preventive, Restorative and Pediatric Dentistry, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland
    • Bönecker, Marcelo. Department of Pediatric Dentistry, School of Dentistry, University of São Paulo, Av. Lineu Prestes, 2227, Butantã, 05508-900, São Paulo, SP, Brazil
    • Altenburger, Markus. Department of Operative Dentistry and Periodontology, University Hospital and Dental School, University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany
    • Buzalaf, Marília. Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Al. Octávio Pinheiro Brisola, 9-75, Vila Unversitária, Caixa Postal 73, 17012-901, Bauru, SP, Brazil
    • Sampaio, Fabio. Health Science Center, Federal University of Paraíba, Laboratório de Biologia Bucal, Castelo Branco, 58051900, João Pessoa, PB, Brazil
    • Lussi, Adrian. Department of Preventive, Restorative and Pediatric Dentistry, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Clinical Oral Investigations, 2015, vol. 19, no. 6, p. 1429-1436. Springer Berlin Heidelberg
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:332315
    Summary
    Objectives: Calcium glycerophosphate (CaGP) was added to fluoride varnishes to analyze their preventive effect on initial enamel erosion and fluoride uptake: potassium hydroxide (KOH)-soluble and KOH-insoluble fluoride bound to enamel. Materials and methods: This study was carried out in two parts. Part 1: 108 enamel samples were randomly distributed into six varnish groups: base varnish (no active ingredients); Duraphat® (2.26%NaF); Duofluorid® (5.63%NaF/CaF2); experimental varnish 1 (1%CaGP/5.63%NaF/CaF2); experimental varnish 2 (5%CaGP/5.63%NaF/CaF2); and no varnish. Cyclic demineralization (90s; citric acid, pH = 3.6) and remineralization (4h) was made once a day, for 3days. Change in surface microhardness (SMH) was measured. Part 2: 60 enamel samples were cut in half and received no varnish (control) or a layer of varnish: Duraphat®, Duofluorid®, experimental varnishes 1 and 2. Then, KOH-soluble and KOH-insoluble fluoride were analyzed using an electrode. Results: After cyclic demineralization, SMH decreased in all samples, but Duraphat® caused less hardness loss. No difference was observed between varnishes containing CaGP and the other varnishes. Similar amounts of KOH-soluble and insoluble fluoride was found in experimental varnish 1 and Duofluorid®, while lower values were found for experimental varnish 2 and Duraphat®. Conclusion: The addition of CaGP to fluoride varnishes did not increase fluoride bound to enamel and did not enhance their protection against initial enamel erosion. Clinical relevance: We observe that the fluoride varnishes containing CaGP do not promote greater amounts of fluoride bound to enamel and that fluoride bound to enamel may not be closely related to erosion prevention.