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Physical Activity and the Frequency of Acute Exacerbations in Patients with Chronic Obstructive Pulmonary Disease

Schönmann, M. ; Sievi, N. ; Clarenbach, C. ; Brack, T. ; Brutsche, M. ; Frey, M. ; Irani, S. ; Leuppi, J. ; Ruediger, J. ; Senn, O. ; Thurnheer, R. ; Kohler, M.

In: Lung, 2015, vol. 193, no. 1, p. 63-70

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    Titel
    • Physical Activity and the Frequency of Acute Exacerbations in Patients with Chronic Obstructive Pulmonary Disease
    Autor
    • Schönmann, M.. Clinical Director Division of Pulmonology, University Hospital of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland
    • Sievi, N.. Clinical Director Division of Pulmonology, University Hospital of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland
    • Clarenbach, C.. Clinical Director Division of Pulmonology, University Hospital of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland
    • Brack, T.. Pulmonary Division, Cantonal Hospital of Glarus, Glarus, Switzerland
    • Brutsche, M.. Pulmonary Division, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland
    • Frey, M.. Pulmonary Division, Clinic Barmelweid, Barmelweid, Switzerland
    • Irani, S.. Pulmonary Division, Cantonal Hospital of Aarau, Aarau, Switzerland
    • Leuppi, J.. University Clinic of Internal Medicine, Cantonal Hospital Baselland and University of Basel, Basel, Switzerland
    • Ruediger, J.. Pulmonary Division, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland
    • Senn, O.. Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland
    • Thurnheer, R.. Pulmonary Division, Cantonal Hospital of Münsterlingen, Münsterlingen, Switzerland
    • Kohler, M.. Clinical Director Division of Pulmonology, University Hospital of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Lung, 2015, vol. 193, no. 1, p. 63-70. Springer US; http://www.springer-ny.com
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:332255
    Summary
    Purpose: Acute exacerbations (AE) in patients with COPD are associated with a decline in lung function, increased risk of hospitalization, and mortality. In this cross-sectional study we tested whether the level of objectively measured daily physical activity and exercise capacity are associated with the number of COPD exacerbations. Methods: In 210 patients with COPD (67% men; mean (SD) age: 63 (8)years) enrolled in The Obstructive Pulmonary Disease Outcomes Cohort of Switzerland (TOPDOCS) physical activity (PA) (steps per day, physical activity level, (PAL)), exercise capacity (6-min walking distance, (6MWD)), comorbidities, lung function, and medication were assessed. Differences between COPD patients with frequent (≥2year) and infrequent (0-1year) exacerbations were assessed. Univariate and multivariate analyses were performed to investigate whether the level of objectively measured daily physical activity and exercise capacity are associated with the number of COPD exacerbations. Results: Patients with frequent AE had a significantly lower FEV1 and 6MWD compared to patients with infrequent AE. In univariate analysis, the number of exacerbations was inversely associated with FEV1, 6MWD, BMI, and smoking status while there was a positive association with RV/TLC and combined inhaled medication. However, there was no significant association with PAL and steps per day. In multivariate analysis, FEV1 and the use of combined inhaled medication were independently associated with the number of AE, after correction for covariates. Conclusions: The findings of this study imply that FEV1, independent of inhaled medication, is significantly associated with COPD exacerbations. Neither physical activity nor exercise capacity was independently associated with COPD exacerbations.