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Low efficacy of albendazole against Trichuris trichiura infection in schoolchildren from Port Elizabeth, South Africa

Müller, Ivan ; Beyleveld, Lindsey ; Gerber, Markus ; Pühse, Uwe ; du Randt, Rosa ; Utzinger, Jürg ; Zondie, Leyli ; Walter, Cheryl ; Steinmann, Peter

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2016, vol. 110, no. 11, p. 676-678

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    Titel
    • Low efficacy of albendazole against Trichuris trichiura infection in schoolchildren from Port Elizabeth, South Africa
    Autor
    • Müller, Ivan. Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland
    • Beyleveld, Lindsey. Department of Medical Laboratory Sciences, Nelson Mandela Metropolitan University, P.O. Box 77000, Port Elizabeth 6031, South Africa
    • Gerber, Markus. Department of Sport, Exercise and Health, University of Basel, St. Jakobsturm, Birsstrasse 320B, CH-4056 Basel, Switzerland
    • Pühse, Uwe. Department of Sport, Exercise and Health, University of Basel, St. Jakobsturm, Birsstrasse 320B, CH-4056 Basel, Switzerland
    • du Randt, Rosa. Department of Human Movement Science, Nelson Mandela Metropolitan University, P.O. Box 77000, Port Elizabeth 6031, South Africa
    • Utzinger, Jürg. Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland
    • Zondie, Leyli. Department of Medical Laboratory Sciences, Nelson Mandela Metropolitan University, P.O. Box 77000, Port Elizabeth 6031, South Africa
    • Walter, Cheryl. Department of Human Movement Science, Nelson Mandela Metropolitan University, P.O. Box 77000, Port Elizabeth 6031, South Africa
    • Steinmann, Peter. Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Transactions of The Royal Society of Tropical Medicine and Hygiene, 2016, vol. 110, no. 11, p. 676-678. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:332201
    Summary
    Abstract Background Albendazole is one of two standard drugs for the control of soil-transmitted helminthiasis. Methods A total of 149 schoolchildren from Port Elizabeth, South Africa, were examined for soil-transmitted helminth infections using duplicate Kato-Katz thick smears before and 2 weeks after administration of albendazole (400 mg). Results Trichuris trichiura was the predominant soil-transmitted helminth species (prevalence 60.4%), followed by Ascaris lumbricoides (47.7%). While albendazole was highly efficacious against A. lumbricoides (cure rate [CR] 97.2%; egg reduction rate [ERR] 94.3%), it lacked efficacy against T. trichiura (CR 1.1%; ERR 46.0%). Conclusions Our study confirms low efficacy of single dose albendazole against T. trichiura. There is a need for safe and efficacious drugs against T. trichiura.