Fulltext

Osseointegration of titanium implants functionalised with phosphoserine-tethered poly(epsilon-lysine) dendrons: a comparative study with traditional surface treatments in sheep

Stübinger, Stefan ; Nuss, Katja ; Bürki, Alexander ; Mosch, Isabel ; le Sidler, Miché ; Meikle, Steve ; von Rechenberg, Brigitte ; Santin, Matteo

In: Journal of Materials Science: Materials in Medicine, 2015, vol. 26, no. 2, p. 1-12

Add to personal list
    Title
    • Osseointegration of titanium implants functionalised with phosphoserine-tethered poly(epsilon-lysine) dendrons: a comparative study with traditional surface treatments in sheep
    Author
    • Stübinger, Stefan. Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty ZH, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland
    • Nuss, Katja. Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty ZH, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland
    • Bürki, Alexander. Institute for Surgical Biotechnology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland
    • Mosch, Isabel. Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty ZH, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland
    • le Sidler, Miché. Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty ZH, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland
    • Meikle, Steve. Brighton Studies in Tissue-mimicry and Aided Regeneration, Brighton Centre for Regenerative Medicine, University of Brighton, Huxley Building Lewes Road, BN2 4GJ, Brighton, UK
    • von Rechenberg, Brigitte. Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty ZH, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland
    • Santin, Matteo. Brighton Studies in Tissue-mimicry and Aided Regeneration, Brighton Centre for Regenerative Medicine, University of Brighton, Huxley Building Lewes Road, BN2 4GJ, Brighton, UK
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Materials Science: Materials in Medicine, 2015, vol. 26, no. 2, p. 1-12. Springer US; http://www.springer-ny.com
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:332094
    Summary
    The aim of this study was to analyse the osseointegrative potential of phosphoserine-tethered dendrons when applied as surface functionalisation molecules on titanium implants in a sheep model after 2 and 8weeks of implantation. Uncoated and dendron-coated implants were implanted in six sheep. Sandblasted and etched (SE) or porous additive manufactured (AM) implants with and without additional dendron functionalisation (SE-PSD; AM-PSD) were placed in the pelvic bone. Three implants per group were examined histologically and six implants were tested biomechanically. After 2 and 8weeks the bone-to-implant contact (BIC) total values of SE implants (43.7±12.2; 53.3±9.0%) and SE-PSD (46.7±4.5; 61.7±4.9%) as well as AM implants (20.49±5.1; 43.9±9.7%) and AM-PSD implants (19.7±3.5; 48.3±15.6%) showed no statistically significant differences. For SE-PSD and AM-PSD a separate analysis of only the cancellous BIC demonstrated a statistically significant difference after 2 and 8weeks. Biomechanical findings proved the overall increased stability of the porous implants after 8weeks. Overall, the great effect of implant macro design on osseointegration was further supported by additional phosphoserine-tethered dendrons for SE and AM implants.