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mTOR in health and in sickness

Liko, Dritan ; Hall, Michael

In: Journal of Molecular Medicine, 2015, vol. 93, no. 10, p. 1061-1073

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    Titre
    • mTOR in health and in sickness
    Auteur
    • Liko, Dritan. Biozentrum, University of Basel, 4056, Basel, Switzerland
    • Hall, Michael. Biozentrum, University of Basel, 4056, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Molecular Medicine, 2015, vol. 93, no. 10, p. 1061-1073. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:331631
    Summary
    Target of rapamycin (TOR) is a highly conserved protein kinase that plays a key role in mediating cell growth and homeostasis. It is activated by nutrients, growth factors, and cellular energy levels to control a number of anabolic and catabolic processes. It is a validated drug target implicated in a variety of diseases. In this review, we describe the molecular mode of action of TOR in the context of cellular and organismal physiology. We focus on mammalian TOR (mTOR) signaling in cancer and neurological disease and discuss usage of TOR inhibitors in the clinic.