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Contribution of acoustic radiation force impulse (ARFI) elastography to the ultrasound diagnosis of biliary atresia

Hanquinet, Sylviane ; Courvoisier, Delphine ; Rougemont, Anne-Laure ; Dhouib, Amira ; Rubbia-Brandt, Laura ; Wildhaber, Barbara ; Merlini, Laura ; McLin, Valerie ; Anooshiravani, Mehrak

In: Pediatric Radiology, 2015, vol. 45, no. 10, p. 1489-1495

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    Titre
    • Contribution of acoustic radiation force impulse (ARFI) elastography to the ultrasound diagnosis of biliary atresia
    Auteur
    • Hanquinet, Sylviane. Department of Pediatric Radiology, University Children's Hospital, 6 rue Willy Donzé, Ch 1211, Geneva 14, Switzerland
    • Courvoisier, Delphine. Division of Clinical Epidemiology, University of Geneva, Geneva, Switzerland
    • Rougemont, Anne-Laure. Division of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland
    • Dhouib, Amira. Department of Pediatric Radiology, University Children's Hospital, 6 rue Willy Donzé, Ch 1211, Geneva 14, Switzerland
    • Rubbia-Brandt, Laura. Division of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland
    • Wildhaber, Barbara. Department of Pediatric Surgery, Children's University Hospital of Geneva, Geneva, Switzerland
    • Merlini, Laura. Department of Pediatric Radiology, University Children's Hospital, 6 rue Willy Donzé, Ch 1211, Geneva 14, Switzerland
    • McLin, Valerie. Department of Pediatric Gastroenterology, Children's University Hospital of Geneva, Geneva, Switzerland
    • Anooshiravani, Mehrak. Department of Pediatric Radiology, University Children's Hospital, 6 rue Willy Donzé, Ch 1211, Geneva 14, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Pediatric Radiology, 2015, vol. 45, no. 10, p. 1489-1495. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:331565
    Summary
    Background: Children with biliary atresia rapidly develop liver fibrosis secondary to inflammatory destruction of the biliary tract. Noninvasive detection of liver fibrosis in neonatal/infantile cholestasis is an additional criterion for the diagnosis of biliary atresia, leading to prompt surgical exploration. Objective: To assess the value of US with acoustic radiation force impulse (ARFI) elastography to detect biliary atresia in the workup of neonatal/infantile cholestasis. Materials and methods: In this retrospective study, 20 children with cholestasis suspected of having biliary atresia were investigated by US and ARFI. We evaluated the association between US findings and the diagnosis of biliary atresia and with two scores of liver fibrosis obtained from liver biopsy. Results: In univariate analyses, gallbladder size, triangular cord sign, spleen size and ARFI values were found to be associated with biliary atresia, though only the triangular cord sign remained significant when elevated gamma glutamyltransferase (GGT) was included as a predictor. In contrast, spleen size and ARFI correlated with the degree of liver fibrosis on biopsy (r > 0.70, P < 0.001), which remained significant when gamma glutamyltransferase elevation was included as a predictor. Conclusion: The addition of ARFI to a standard abdominal US in the initial workup of the neonate with possible infantile cholestasis can provide reliable information on liver fibrosis and help in the diagnosis of biliary atresia.