Role of connexins and pannexins in cardiovascular physiology
Meens, Merlijn ; Kwak, Brenda ; Duffy, Heather
In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 15, p. 2779-2792
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- Connexins and pannexins form connexons, pannexons and membrane channels, which are critically involved in many aspects of cardiovascular physiology. For that reason, a vast number of studies have addressed the role of connexins and pannexins in the arterial and venous systems as well as in the heart. Moreover, a role for connexins in lymphatics has recently also been suggested. This review provides an overview of the current knowledge regarding the involvement of connexins and pannexins in cardiovascular physiology.