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Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis

Barro, Christian ; Benkert, Pascal ; Disanto, Giulio ; Tsagkas, Charidimos ; Amann, Michael ; Naegelin, Yvonne ; Leppert, David ; Gobbi, Claudio ; Granziera, Cristina ; Yaldizli, Özgür ; Michalak, Zuzanna ; Wuerfel, Jens ; Kappos, Ludwig ; Parmar, Katrin ; Kuhle, Jens

In: Brain, 2018, vol. 141, no. 8, p. 2382-2391

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    Titre
    • Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis
    Auteur
    • Barro, Christian. Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    • Benkert, Pascal. Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    • Disanto, Giulio. Neurocentre of Southern Switzerland, Ospedale Civico, Lugano, Switzerland
    • Tsagkas, Charidimos. Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    • Amann, Michael. Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    • Naegelin, Yvonne. Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    • Leppert, David. Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    • Gobbi, Claudio. Neurocentre of Southern Switzerland, Ospedale Civico, Lugano, Switzerland
    • Granziera, Cristina. Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    • Yaldizli, Özgür. Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    • Michalak, Zuzanna. Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    • Wuerfel, Jens. Medical Image Analysis Center (MIAC AG), Basel, Switzerland
    • Kappos, Ludwig. Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    • Parmar, Katrin. Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    • Kuhle, Jens. Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Brain, 2018, vol. 141, no. 8, p. 2382-2391. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:331389
    Summary
    See Giovannoni (doi:10.1093/brain/awy200) for a scientific commentary on this article. Biomarkers of tissue damage in multiple sclerosis are urgently needed. Barro et al. show that serum neurofilament light chain (NfL) levels are increased in patients versus healthy controls and reflect radiological and clinical disease activity and progression. High serum NfL is associated with greater subsequent brain and spinal cord atrophy.