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Disrupted prediction errors index social deficits in autism spectrum disorder

Balsters, Joshua H. ; Apps, Matthew A J. ; Bolis, Dimitris ; Lehner, Rea ; Gallagher, Louise ; Wenderoth, Nicole

In: Brain, 2017, vol. 140, no. 1, p. 235-246

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    Title
    • Disrupted prediction errors index social deficits in autism spectrum disorder
    Author
    • Balsters, Joshua H.. 1 Neural Control of Movement Laboratory, Department of Health Sciences and Technology, ETH Zurich, Switzerland
    • Apps, Matthew A J.. 3 Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK
    • Bolis, Dimitris. 1 Neural Control of Movement Laboratory, Department of Health Sciences and Technology, ETH Zurich, Switzerland
    • Lehner, Rea. 1 Neural Control of Movement Laboratory, Department of Health Sciences and Technology, ETH Zurich, Switzerland
    • Gallagher, Louise. 4 Department of Psychiatry and Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    • Wenderoth, Nicole. 1 Neural Control of Movement Laboratory, Department of Health Sciences and Technology, ETH Zurich, Switzerland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:331257
    Summary
    In healthy individuals the anterior cingulate gyrus signals social prediction errors: discrepancies between an actual outcome and the perceived expectations of another person. Balsters et al. demonstrate that this crucial social signal is altered in individuals with autism, and that variability in social prediction error signalling indexes social symptom severity.