Soft, implantable bioelectronic interfaces for translational research
- Schiavone, Giuseppe Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne Geneva 1202 Switzerland
- Fallegger, Florian Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne Geneva 1202 Switzerland
- Kang, Xiaoyang Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne Geneva 1202 Switzerland
- Barra, Beatrice Department of Neuroscience and Movement Science, University of Fribourg Fribourg 1700 Switzerland
- Vachicouras, Nicolas Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne Geneva 1202 Switzerland
- Roussinova, Evgenia Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne Geneva 1202 Switzerland
- Furfaro, Ivan Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne Geneva 1202 Switzerland
- Jiguet, Sébastien Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne Geneva 1202 Switzerland
- Seáñez, Ismael Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne Lausanne 1015 Switzerland
- Borgognon, Simon Department of Neuroscience and Movement Science, University of Fribourg Fribourg 1700 Switzerland - Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne Lausanne 1015 Switzerland
- Rowald, Andreas Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne Lausanne 1015 Switzerland
- Li, Qin Institute of Lab Animal Sciences, China Academy of Medical Sciences Beijing 100021 China - Motac Neuroscience Ltd Manchester SK10 4TF UK
- Qin, Chuan Institute of Lab Animal Sciences, China Academy of Medical Sciences Beijing 100021 China
- Bézard, Erwan Institute of Lab Animal Sciences, China Academy of Medical Sciences Beijing 100021 China - Motac Neuroscience Ltd Manchester SK10 4TF UK - Institut des Maladies Neurodégénératives, University of Bordeaux Bordeaux UMR 5293 France - CNRSInstitut des Maladies Neurodégénératives Bordeaux UMR 5293 France
- Bloch, Jocelyne Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne Lausanne 1015 Switzerland - Defitech Center for Interventional Neurotherapies (Neuro, Restore)Department of Neurosurgery, University Hospital of Lausanne (CHUV)University of Lausanne (UNIL) Lausanne Switzerland
- Courtine, Grégoire Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne Lausanne 1015 Switzerland - Defitech Center for Interventional Neurotherapies (Neuro, Restore)Department of Neurosurgery, University Hospital of Lausanne (CHUV)University of Lausanne (UNIL) Lausanne Switzerland
- Capogrosso, Marco Department of Neuroscience and Movement Science, University of Fribourg Fribourg 1700 Switzerland
- Lacour, Stéphanie P. Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne Geneva 1202 Switzerland
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01.04.2020
Published in:
- Advanced Materials. - 2020, vol. 32, no. 17, p. 1906512
English
The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐ based innovation toward clinical use calls for further advances in materials, manufacturing and characterization paradigms, and design rules. Herein, a translational framework engineered to accelerate the deployment of microfabricated interfaces for translational research is proposed and applied to the soft neurotechnology called electronic dura mater, e‐dura. Anatomy, implant function, and surgical procedure guide the system design. A high‐yield, silicone‐ on‐silicon wafer process is developed to ensure reproducible characteristics of the electrodes. A biomimetic multimodal platform that replicates surgical insertion in an anatomy‐based model applies physiological movement, emulates therapeutic use of the electrodes, and enables advanced validation and rapid optimization in vitro of the implants. Functionality of scaled e‐dura is confirmed in nonhuman primates, where epidural neuromodulation of the spinal cord activates selective groups of muscles in the upper limbs with unmet precision. Performance stability is controlled over 6 weeks in vivo. The synergistic steps of design, fabrication, and biomimetic in vitro validation and in vivo evaluation in translational animal models are of general applicability and answer needs in multiple bioelectronic designs and medical technologies.Supporting Information
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 328538
- DOI 10.1002/adma.201906512
- Persistent URL
- https://folia.unifr.ch/unifr/documents/308522
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