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Focal hemodynamic patterns of status epilepticus detected by susceptibility weighted imaging (SWI)

Aellen, Jerome ; Abela, Eugenio ; Buerki, Sarah ; Kottke, Raimund ; Springer, Elisabeth ; Schindler, Kaspar ; Weisstanner, Christian ; El-Koussy, Marwan ; Schroth, Gerhard ; Wiest, Roland ; Gralla, Jan ; Verma, Rajeev

In: European Radiology, 2014, vol. 24, no. 11, p. 2980-2988

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    Titel
    • Focal hemodynamic patterns of status epilepticus detected by susceptibility weighted imaging (SWI)
    Autor
    • Aellen, Jerome. University Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern and Inselspital, University of Bern, Freiburgstrasse 4, 3010, Bern, Switzerland
    • Abela, Eugenio. Department of Neurology, Inselspital, University of Bern, Bern, Switzerland
    • Buerki, Sarah. Department of Neuropaediatrics, University Children's Hospital, Inselspital, Bern, Switzerland
    • Kottke, Raimund. University Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern and Inselspital, University of Bern, Freiburgstrasse 4, 3010, Bern, Switzerland
    • Springer, Elisabeth. University Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern and Inselspital, University of Bern, Freiburgstrasse 4, 3010, Bern, Switzerland
    • Schindler, Kaspar. Department of Neurology, Inselspital, University of Bern, Bern, Switzerland
    • Weisstanner, Christian. University Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern and Inselspital, University of Bern, Freiburgstrasse 4, 3010, Bern, Switzerland
    • El-Koussy, Marwan. University Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern and Inselspital, University of Bern, Freiburgstrasse 4, 3010, Bern, Switzerland
    • Schroth, Gerhard. University Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern and Inselspital, University of Bern, Freiburgstrasse 4, 3010, Bern, Switzerland
    • Wiest, Roland. University Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern and Inselspital, University of Bern, Freiburgstrasse 4, 3010, Bern, Switzerland
    • Gralla, Jan. University Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern and Inselspital, University of Bern, Freiburgstrasse 4, 3010, Bern, Switzerland
    • Verma, Rajeev. University Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern and Inselspital, University of Bern, Freiburgstrasse 4, 3010, Bern, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • European Radiology, 2014, vol. 24, no. 11, p. 2980-2988. Springer Berlin Heidelberg
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:326607
    Summary
    Objective: To investigate pathological findings in the susceptibility weighted imaging (SWI) of patients experiencing convulsive (CSE) or non-convulsive status epilepticus (NCSE) with focal hyperperfusion in the acute setting. Methods: Twelve patients (six with NCSE confirmed by electroencephalogram (EEG) and six patients with CSE with seizure event clinically diagnosed) underwent MRI in this acute setting (mean time between onset of symptoms and MRI was 3h 8min), including SWI, dynamic susceptibility contrast MR imaging (DSC) and diffusion-weighted imaging (DWI). MRI sequences were retrospectively evaluated and compared with EEG findings (10/12 patients), and clinical symptoms. Results: Twelve out of 12 (100%) patients showed a focal parenchymal area with pseudo-narrowed cortical veins on SWI, associated with focal hyperperfused areas (increased cerebral blood flow (CBF) and mean transit time (MTT) shortening), and cortical DWI restriction in 6/12 patients (50%). Additionally, these areas were associated with ictal or postical EEG patterns in 8/10 patients (80%). Most frequent acute clinical findings were aphasia and/or hemiparesis in eight patients, and all of them showed pseudo-narrowed veins in those parenchymal areas responsible for these symptoms. Conclusion: In this study series with CSE and NCSE patients, SWI showed focally pseudo-narrowed cortical veins in hyperperfused and ictal parenchymal areas. Therefore, SWI might have the potential to identify an ictal region in CSE/NCSE. Key Points : • The focal ictal brain regions show hyperperfusion in DSC MR-perfusion imaging. • SWI shows focally diminished cortical veins in hyperperfused ictal regions. • SWI has the potential to identify a focal ictal region in CSE/NCSE.