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Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis

Kakeda, M. ; Schlapbach, Christoph ; Danelon, G. ; Tang, M. ; Cecchinato, V. ; Yawalkar, N. ; Uguccioni, M.

In: Archives of Dermatological Research, 2014, vol. 306, no. 10, p. 933-938

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    Title
    • Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis
    Author
    • Kakeda, M.. Department of Dermatology, Inselspital Bern University Hospital, 3010, Bern, Switzerland
    • Schlapbach, Christoph. Department of Dermatology, Inselspital Bern University Hospital, 3010, Bern, Switzerland
    • Danelon, G.. Institute for Research in Biomedicine, Bellinzona, Switzerland
    • Tang, M.. Department of Dermatology, Inselspital Bern University Hospital, 3010, Bern, Switzerland
    • Cecchinato, V.. Institute for Research in Biomedicine, Bellinzona, Switzerland
    • Yawalkar, N.. Department of Dermatology, Inselspital Bern University Hospital, 3010, Bern, Switzerland
    • Uguccioni, M.. Institute for Research in Biomedicine, Bellinzona, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Archives of Dermatological Research, 2014, vol. 306, no. 10, p. 933-938. Springer Berlin Heidelberg
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:326160
    Summary
    Acute generalized exanthematous pustulosis (AGEP) and generalized pustular psoriasis (GPP) are rare pustular skin disorders with systemic involvement. IL-17A/F is a proinflammatory cytokine involved in various neutrophilic inflammatory disorders. Here we show that IL-17A/F is highly expressed by innate immune cells such as neutrophils and mast cells in both AGEP and GPP.