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Decreased levels of homoarginine and asymmetric dimethylarginine in children with type 1 diabetes: associations with cardiovascular risk factors but no effect by atorvastin

Krebs, Andreas ; Doerfer, Jürgen ; Grünert, Sarah Catherina ; Wöhrl, Jan ; Stier, Bernhard ; Schmidt-Trucksäss, Arno ; Lichte, Kai ; Winkler, Karl ; Grulich-Henn, Jürgen ; Holder, Martin ; Schwab, Karl Otfried

In: Journal of Pediatric Endocrinology and Metabolism, 2015, vol. 28, no. 1-2, p. 147-152

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    Titel
    • Decreased levels of homoarginine and asymmetric dimethylarginine in children with type 1 diabetes: associations with cardiovascular risk factors but no effect by atorvastin
    Autor
    • Krebs, Andreas. Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany
    • Doerfer, Jürgen. Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany
    • Grünert, Sarah Catherina. Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany
    • Wöhrl, Jan. Department of Clinical Chemistry, University Medical Center, Freiburg, Germany
    • Stier, Bernhard. Practice for Pediatrics and Adolescent Medicine, Butzbach, Germany
    • Schmidt-Trucksäss, Arno. Institute of Exercise and Health Sciences, Department Sports Medicine, University of Basel, Basel, Switzerland
    • Lichte, Kai. Clinic for Pediatrics and Adolescent Medicine, Schwarzwald-Baar Medical Center, Villingen-Schwenningen, Germany
    • Winkler, Karl. Department of Clinical Chemistry, University Medical Center, Freiburg, Germany
    • Grulich-Henn, Jürgen. Department of Pediatrics and Adolescent Medicine, University Medical Center, Heidelberg, Germany
    • Holder, Martin. Children's Hospital, Olgahospital, Stuttgart, Germany
    • Schwab, Karl Otfried. Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Journal of Pediatric Endocrinology and Metabolism, 2015, vol. 28, no. 1-2, p. 147-152. De Gruyter
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:325983
    Summary
    Objectives: To investigate homoarginine and asymmetric dimethylarginine (ADMA) in controls compared to children with type 1 diabetes (T1D) and if homoarginine and ADMA are affected by atorvastatin. Methods: Homoarginine and ADMA levels of 28 T1D patients were compared to levels of 41 controls. In T1D patients, homoarginine and ADMA were determined at baseline, 1 year, and 2 years at daily 10 mg atorvastatin or placebo within a double-blind study. Results: At baseline, both homoarginine and ADMA were lower (p<0.001) in T1D patients compared to controls. In T1D patients, homoarginine and ADMA were not influenced by atorvastatin. Inverse correlations between homoarginine and HbA1c (p<0.001) and between ADMA and systolic blood pressure (p=0.005) and pulse pressure (p=0.003) were shown. Conclusions: Homoarginine and ADMA levels are decreased and associated with cardiovascular risk factors in children with T1D without being affected by atorvastatin.