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Immunological aspects of atherosclerosis

Garrido-Urbani, S. ; Meguenani, M. ; Montecucco, F. ; Imhof, B.

In: Seminars in Immunopathology, 2014, vol. 36, no. 1, p. 73-91

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    Titre
    • Immunological aspects of atherosclerosis
    Auteur
    • Garrido-Urbani, S.. Department of Pathology and Immunology, CMU, University of Geneva, Geneva, Switzerland
    • Meguenani, M.. Department of Pathology and Immunology, CMU, University of Geneva, Geneva, Switzerland
    • Montecucco, F.. Cardiology Division, Department of Medical Specialties, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland
    • Imhof, B.. Department of Pathology and Immunology, CMU, University of Geneva, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Seminars in Immunopathology, 2014, vol. 36, no. 1, p. 73-91. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:325779
    Summary
    Atherosclerosis is a complex chronic inflammatory and metabolic disease that involves the collaboration of several cellular components of the immune system and results in thickening of the arterial wall. Atherosclerosis is also the primary cause of coronary artery and cerebrovascular diseases. A multitude of immune cell subsets, soluble molecules such as chemokines and cytokines, and circulating lipids play pivotal roles in atherosclerosis development. In this review, we highlight the role of the immune system in the course of atherosclerotic disease development and discuss the mechanisms involved.