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Incidence of second sarcomas: a cancer registry-based study

Levi, Fabio ; Randimbison, Lalao ; Maspoli-Conconi, Manuela ; Blanc-Moya, Rafael ; La Vecchia, Carlo

In: Cancer Causes & Control, 2014, vol. 25, no. 4, p. 473-477

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    Titel
    • Incidence of second sarcomas: a cancer registry-based study
    Autor
    • Levi, Fabio. Vaud Cancer Registry and Cancer Epidemiology Unit, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010, Lausanne, Switzerland
    • Randimbison, Lalao. Vaud Cancer Registry and Cancer Epidemiology Unit, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010, Lausanne, Switzerland
    • Maspoli-Conconi, Manuela. Department of Health and Social Affairs, Neuchâtel Cancer Registry, Av. des Cadolles 7, 2000, Neuchâtel, Switzerland
    • Blanc-Moya, Rafael. Vaud Cancer Registry and Cancer Epidemiology Unit, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010, Lausanne, Switzerland
    • La Vecchia, Carlo. Department of Epidemiology, IRCCS-Pharmacological Research Institute "Mario Negri”, Via G. La Masa 19, 20156, Milan, Italy
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Cancer Causes & Control, 2014, vol. 25, no. 4, p. 473-477. Springer International Publishing
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:325371
    Summary
    Background: In high-quality cancer registration systems, about one in eight incident cancers are second primary cancers. This is due to a combination of careful diagnostic ascertainment, shared genetic determinants, shared exposure to environmental factors and consequences of treatment for first cancer. Methods: We used data derived from the Swiss population-based cancer Registries of Vaud and Neuchâtel, including 885,000 inhabitants. Results: Among 107,238 (52% males) first cancers occurring between 1976 and 2010, a total of 126 second sarcomas were observed through active and passive follow-up versus 68.2 expected, corresponding to a standardized incidence ratio (SIR) of 1.85 (95% CI 1.5-2.2). Significant excess sarcoma risks were observed after skin melanoma (SIR=3.0), breast cancer (2.2), corpus uteri (2.7), testicular (7.5), thyroid cancer (4.2), Hodgkin lymphoma (5.7) and leukemias (4.0). For breast cancer, the SIR was 3.4 ≥5years after sarcoma diagnosis. Conclusions: The common denominator of these neoplasms is the utilization of radiotherapy in their management. Some sarcomas following breast cancer may be due to shared genetic components (i.e., in the Li-Fraumeni syndrome), as well as possibly to shared environmental factors, with sarcomas, including overweight, selected dietary and reproductive factors which are, however, too little defined for any quantitative risk assessment.