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Tight junction dynamics: the role of junctional adhesion molecules (JAMs)

Garrido-Urbani, S. ; Bradfield, P. ; Imhof, B.

In: Cell and Tissue Research, 2014, vol. 355, no. 3, p. 701-715

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    Titre
    • Tight junction dynamics: the role of junctional adhesion molecules (JAMs)
    Auteur
    • Garrido-Urbani, S.. Department of Pathology and Immunology, CMU, University of Geneva, Geneva, Switzerland
    • Bradfield, P.. Department of Pathology and Immunology, CMU, University of Geneva, Geneva, Switzerland
    • Imhof, B.. Department of Pathology and Immunology, CMU, University of Geneva, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cell and Tissue Research, 2014, vol. 355, no. 3, p. 701-715. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:325331
    Summary
    Junctional adhesion molecules (JAMs) are a family of adhesion molecules localized at the tight junction of polarized cells and on the cell surface of leukocytes. The last 20years of research in this field has shown that several members of the family play an important role in the regulation of cell polarity, endothelium permeability and leukocytes migration. They mediate these pleiotropic functions through a multitude of homophilic and heterophilic interactions with intrafamily and extrafamily partners. In this article, we review the current status of the JAM family and highlight their functional role in tight junction dynamics and leukocyte transmigration.