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Biomarkers in renal cancer

Moch, Holger ; Srigley, John ; Delahunt, Brett ; Montironi, Rodolfo ; Egevad, Lars ; Tan, Puay

In: Virchows Archiv, 2014, vol. 464, no. 3, p. 359-365

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    Titre
    • Biomarkers in renal cancer
    Auteur
    • Moch, Holger. Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091, Zürich, Switzerland
    • Srigley, John. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    • Delahunt, Brett. Department of Pathology and Molecular Medicine, University of Otago, Wellington, New Zealand
    • Montironi, Rodolfo. Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    • Egevad, Lars. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
    • Tan, Puay. Department of Pathology, Singapore General Hospital, Singapore, Singapore
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Virchows Archiv, 2014, vol. 464, no. 3, p. 359-365. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:325146
    Summary
    Treatment options for primary and metastatic renal cancer are increasing. Accurate data from the pathological examination of renal cancer specimens aid clinicians in stratifying patients for surveillance and adjuvant therapies. This review focuses on biomarkers in diagnosis, prognosis and prediction of the biologic behavior of renal tumors which should be recorded in pathology reports and which are under investigation. Special emphasis is given to the use of immunohistochemical markers in differential diagnosis of various renal tumor subtypes. The relevance of cytogenetic and molecular findings is also discussed. The review includes the 2012 International Society for Urological Pathology Consensus conference recommendations.