Fulltext

Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

Bartl, Jasmin ; Müller, Thomas ; Grünblatt, Edna ; Gerlach, Manfred ; Riederer, Peter

In: Journal of Neural Transmission, 2014, vol. 121, no. 4, p. 379-383

Zum persönliche Liste hinzufügen
    Titel
    • Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity
    Autor
    • Bartl, Jasmin. Hospital of Child and Adolescent Psychiatry, University of Zurich, Winterthurerstr. 180, Room L84/86, 8057, Zurich, Switzerland
    • Müller, Thomas. Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Berlin, Germany
    • Grünblatt, Edna. Hospital of Child and Adolescent Psychiatry, University of Zurich, Winterthurerstr. 180, Room L84/86, 8057, Zurich, Switzerland
    • Gerlach, Manfred. Department of Child and Adolescents Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wuerzburg, University of Wuerzburg, Wuerzburg, Germany
    • Riederer, Peter. Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wuerzburg, University of Wuerzburg, Wuerzburg, Germany
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Journal of Neural Transmission, 2014, vol. 121, no. 4, p. 379-383. Springer Vienna
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:325113
    Summary
    Patients with Parkinson's disease receive selective irreversible monoamine oxidase (MAO)-B inhibitors, but their effects on MAO-A activity are not known during long-term application. We determined MAO-A inhibition in plasma samples from patients with MAO-B inhibitor intake or without MAO-B inhibitor treatment and from healthy controls. We detected a 70% reduction of MAO-A activity in patients with MAO-B inhibitor therapy in comparison to the other groups. Our results suggest that treatment with MAO-B inhibitor may also influence MAO-A activity in vivo, when administered daily.