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Diarrheagenic enteroaggregative Escherichia coli causing urinary tract infection and bacteremia leading to sepsis

Herzog, K. ; Engeler Dusel, J. ; Hugentobler, M. ; Beutin, L. ; Sägesser, G. ; Stephan, R. ; Hächler, H. ; Nüesch-Inderbinen, M.

In: Infection, 2014, vol. 42, no. 2, p. 441-444

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    Titre
    • Diarrheagenic enteroaggregative Escherichia coli causing urinary tract infection and bacteremia leading to sepsis
    Auteur
    • Herzog, K.. Institute of Laboratory Medicine, Cantonal Hospital Frauenfeld, 8501, Frauenfeld, Switzerland
    • Engeler Dusel, J.. Department of Nephrology and Internal Medicine, Cantonal Hospital Frauenfeld, 8501, Frauenfeld, Switzerland
    • Hugentobler, M.. Department of Nephrology and Internal Medicine, Cantonal Hospital Frauenfeld, 8501, Frauenfeld, Switzerland
    • Beutin, L.. National Reference Laboratory for Escherichia coli, Federal Institute for Risk Assessment, Berlin, Germany
    • Sägesser, G.. National Centre for Enteropathogenic Bacteria and Listeria, Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Winterthurerstr. 272, 8057, Zurich, Switzerland
    • Stephan, R.. National Centre for Enteropathogenic Bacteria and Listeria, Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Winterthurerstr. 272, 8057, Zurich, Switzerland
    • Hächler, H.. National Centre for Enteropathogenic Bacteria and Listeria, Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Winterthurerstr. 272, 8057, Zurich, Switzerland
    • Nüesch-Inderbinen, M.. National Centre for Enteropathogenic Bacteria and Listeria, Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Winterthurerstr. 272, 8057, Zurich, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:325078
    Summary
    We report a case of a 55-year-old immunocompromised female who presented to the emergency department with severe diarrhea and vomiting following travel to the Philippines. Stool bacteriology revealed a mixed infection involving an enteropathogenic Escherichia coli and two distinct strains of enteroaggregative Escherichia coli (EAEC). During hospitalization, urine and blood culture tested positive for one of the diarrheagenic EAEC strains, necessitating urinary catheterization, intensive care, and antimicrobial treatment with trimethoprim-sulfamethoxazole, followed by meropenem. Although known to occasionally cause urinary tract infections, EAEC have not been previously associated with sepsis. Our report highlights the potential of EAEC to cause severe extraintestinal infections.