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Tissue distribution, antigen specificity and effector functions of γδ T cells in human diseases

De Libero, Gennaro

In: Springer Seminars in Immunopathology, 2000, vol. 22, no. 3, p. 219-238

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    Title
    • Tissue distribution, antigen specificity and effector functions of γδ T cells in human diseases
    Author
    • De Libero, Gennaro. Experimental Immunology, University Hospital, Hebelstrasse 20, 4031, Basel, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Springer Seminars in Immunopathology, 2000, vol. 22, no. 3, p. 219-238. Springer-Verlag
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:322012
    Summary
    Conclusions: In conclusion, the large number of studies on human γδ T cells have shown that these lymphocytes share several characteristics in common with αβ T cells, and also embody many unique properties. Some investigations have perhaps suffered a constant analogy with the αβ T cell population, which has precluded new and original experimental approaches. Nevertheless, this gigantic amount of work has provided solid clues for defining the role of human γδ T cells in diseases. In addition, we have also learnt more about the extreme plasticity of the immune system and its polymorphic capacity to adapt and recognize foreign molecules