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Utrophin is lacking at the neuromuscular junctions in the extraocular muscles of normal cat: artefact or true?

Assadi, Maziar ; Müntener, Markus

In: Histochemistry and Cell Biology, 2005, vol. 123, no. 2, p. 189-194

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    Titre
    • Utrophin is lacking at the neuromuscular junctions in the extraocular muscles of normal cat: artefact or true?
    Auteur
    • Assadi, Maziar. Institute of Anatomy, University of Zürich-Irchel, Zürich, Switzerland
    • Müntener, Markus. Institute of Anatomy, University of Zürich-Irchel, Zürich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Histochemistry and Cell Biology, 2005, vol. 123, no. 2, p. 189-194. Springer-Verlag; http://www.springer.de
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:321619
    Summary
    Extraocular muscles (EOM) are typically spared in Duchenne muscular dystrophy. We hypothesized that this might be due to different patterns of utrophin expression. The expression of utrophin was examined in EOM of normal cats using immunohistochemical methods and Western blot. For detecting acetylcholine receptors (AChR), we used α-bungarotoxin. Surprisingly, α-bungarotoxin failed to stain the AChR and no expression of utrophin could be detected at the neuromuscular junctions. Our study could indicate that the expression of utrophin is dependent on the structure of the AChR