Fulltext

Hemispheric lateralization of the corticostriatal glutamatergic system in the rat

Capper-Loup, Christine ; Rebell, Dominik ; Kaelin-Lang, Alain

In: Journal of Neural Transmission, 2009, vol. 116, no. 9, p. 1053-1057

Ajouter à la liste personnelle
    Titre
    • Hemispheric lateralization of the corticostriatal glutamatergic system in the rat
    Auteur
    • Capper-Loup, Christine. Department of Neurology and Department of Clinical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    • Rebell, Dominik. Department of Neurology and Department of Clinical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    • Kaelin-Lang, Alain. Department of Neurology and Department of Clinical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Neural Transmission, 2009, vol. 116, no. 9, p. 1053-1057. Springer Vienna
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:321604
    Summary
    Little is known about hemispheric lateralization of subcortical structures. Here, we show a higher expression of the subunit NR2A of the NMDA receptor mRNA in the striatum and of vGluT1 mRNA in the cingulate cortex, in the left hemisphere compared to the right one. This suggests a lateralization of the glutamatergic cortico-subcortical system, at the level of postsynaptic receptors as well as at the level of corticostriatal projections. Such lateralization could play a role in asymmetric diseases like Parkinson's disease