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Substrate and Donor Specificity of Glycosyl Transferases

Ernst, Beat ; Oehrlein, Reinhold

In: Glycoconjugate Journal, 1999, vol. 16, no. 2, p. 161-170

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    Titre
    • Substrate and Donor Specificity of Glycosyl Transferases
    Auteur
    • Ernst, Beat. Institute of Molecular Pharmacy, University of Basel, Totengässlein 3, CH-4057, Basel, Switzerland
    • Oehrlein, Reinhold. Novartis Pharma AG, Department of Transplantation, St. Johann, CH-4002, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Glycoconjugate Journal, 1999, vol. 16, no. 2, p. 161-170. Kluwer Academic Publishers-Plenum Publishers
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:321533
    Summary
    It has been shown that all selectins recognize the carbohydrate epitopes sialyl Lewisx and sialyl Lewisa. For the establishment of the structure-activity relationship, the efficient synthesis of these tetrasaccharides and derivatives is therefore of vital interest. The glycosyl transferase-mediated approach is summarized with emphasis on the use of modified acceptors and modified sugar-nucleotide donors. A survey of the involved enzymes: β(1-3) and β(1-4)galactosyl transferases, α(2-3)sialyl transferase, FucT III and FucT VI reveals that the enzymatic synthesis is highly efficient for the rapid preparation of sialyl Lewisx- and sialyl Lewisa-derivatives