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Total-body contrast-enhanced MRA on a short, wide-bore 1.5-T system: intra-individual comparison of Gd-BOPTA and Gd-DOTA

Rasmus, M. ; Bremerich, J. ; Egelhof, T. ; Huegli, R. ; Bongartz, G. ; Bilecen, D.

In: European Radiology, 2008, vol. 18, no. 10, p. 2265-2273

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    Titel
    • Total-body contrast-enhanced MRA on a short, wide-bore 1.5-T system: intra-individual comparison of Gd-BOPTA and Gd-DOTA
    Autor
    • Rasmus, M.. Department of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Bremerich, J.. Department of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Egelhof, T.. Department of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Huegli, R.. Department of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Bongartz, G.. Department of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Bilecen, D.. Department of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • European Radiology, 2008, vol. 18, no. 10, p. 2265-2273. Springer-Verlag
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:321470
    Summary
    Total-body contrast-enhanced MRA (CE-MRA) provides information of the entire vascular system according to a one-stop-shop approach. Short, wide-bore scanners have not yet been used for total-body CE-MRA, probably due to their restricted field of view in the z-direction. The purpose of this feasibility study is to introduce an image protocol for total-body MRA on a short, wide-bore system. The protocol includes five to six table-moving steps and two injection runs. Two pharmacologically different contrast materials (CM) were applied in ten healthy volunteers in view of possible CM-dependent influences on the protocol outcome (Gd-Bopta, Gd-Dota). Differences consisted of significantly higher CNR with Gd-Bopta with a mean of 73.8 ± 38.7 versus 69.1 ± 34.3 (p = 0.008), significantly better arterial visualization values with Gd-Dota with a mean of 1.26 ± 0.44 versus 1.53 ± 0.73 (p = 0.003) and a tendency to less venous overlay with Gd-Dota, mean 1.19 ± 0.44 and 1.34 ± 0.72, respectively (p = 0.065) (two-tailed Wilcoxon matched-pairs test). Overall 94% of the steps were valued as qualitatively excellent or good. The good results with both CM suggest a transfer to further patient evaluation