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Precolostral serology in calves born from Neospora -seropositive mothers

Staubli, Daniela ; Sager, Heinz ; Haerdi, Corinne ; Haessig, Michael ; Gottstein, Bruno

In: Parasitology Research, 2006, vol. 99, no. 4, p. 398-404

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    Titre
    • Precolostral serology in calves born from Neospora -seropositive mothers
    Auteur
    • Staubli, Daniela. Institute of Parasitology, Vetsuisse Faculty, University of Bern, Laenggass-Strasse 122, CH-3012, Bern, Switzerland
    • Sager, Heinz. Institute of Parasitology, Vetsuisse Faculty, University of Bern, Laenggass-Strasse 122, CH-3012, Bern, Switzerland
    • Haerdi, Corinne. Herd Health, Department of Farm Animals, Vetsuisse Faculty, University of Zurich, Winterthurerstr. 260, CH-8057, Zurich, Switzerland
    • Haessig, Michael. Herd Health, Department of Farm Animals, Vetsuisse Faculty, University of Zurich, Winterthurerstr. 260, CH-8057, Zurich, Switzerland
    • Gottstein, Bruno. Institute of Parasitology, Vetsuisse Faculty, University of Bern, Laenggass-Strasse 122, CH-3012, Bern, Switzerland
    Type de document
    • Postprint
    Classification
    • Biologie, Sciences de la vie
    Identifiant OAI-PMH
    • oai:doc.rero.ch:321396
    Summary
    The present study was designed to exploratively determine (a) how many healthy calves, born from seropositive mothers, were also precolostrally seropositive; (b) how many precolostrally negative calves became postcolostrally positive; and (c) in these calves, how the IgG1/IgG2 situation developed pre- and postcolostrally. All calves were born from mothers that were determined to be seropositive in a conventional Neospora caninum-ELISA and by immunoblotting. When the diagnostic performance of the conventional ELISA was compared with that of immunoblotting and an IgG1/IgG2-ELISA in the calves, the latter two exhibited a higher sensitivity: From a total of 15 precolostral calf sera, 7 were positive in the conventional ELISA (diagnostic sensitivity 47%) compared to 15 that were positive by immunoblotting (diagnostic sensitivity 100%) and 12 that were positive by the IgG1/IgG2-ELISA (diagnostic sensitivity 80%). With regard to IgG1/IgG2 findings in the dams, IgG2 appeared as the dominant subclass in the humoral immune response of adult cattle, while in calves, IgG1 appeared as the main prenatally/precolostrally reactive antibody isotype. Provided that precolostral seropositivity reflects postnatal persistent infection with N. caninum, we then postulate that, basically, all of our study calves born form N. caninum-seropositive mothers were prenatally infected with the parasite, and may, thus, all become members of the next transmitting generation