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Morphological differences in Parkinson's disease with and without rest tremor

Benninger, D. ; Thees, S. ; Kollias, S. ; Bassetti, C. ; Waldvogel, D.

In: Journal of Neurology, 2009, vol. 256, no. 2, p. 256-263

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    Titre
    • Morphological differences in Parkinson's disease with and without rest tremor
    Auteur
    • Benninger, D.. Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10 Room 5N240 (MSC1428), Center Drive, 20892, Bethesda, MD, USA
    • Thees, S.. Dept. of Neuroradiology, University Hospital of Zurich, Zurich, Switzerland
    • Kollias, S.. Dept. of Neuroradiology, University Hospital of Zurich, Zurich, Switzerland
    • Bassetti, C.. Dept. of Neurology, University Hospital of Zurich, Zurich, Switzerland
    • Waldvogel, D.. Dept. of Neurology, University Hospital of Zurich, Zurich, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:321266
    Summary
    Background : Rest tremor is a hallmark of Parkinson's disease (PD), but its pathogenesis remains incompletely understood. Nigro-striatal dopamine deficiency correlates best with bradykinesia, but not with tremor. Oscillating neurons in one or multiple localizations within the basal gangliathalamo-cortical loop may cause rest tremor, and an active contribution of the cerebellum and the cerebello-thalamo-cortical projections has been postulated. Objective : To compare the pattern of grey matter volume in PD patients with and without tremor to identify structural correlates of rest tremor. Methods : Voxel-based morphometry (VBM) of a high-resolution 3 Tesla, T1-weighted MR images, pre-processed according to an optimized protocol using SPM2, was performed in 24 patients with mild to moderate PD comparing local grey matter volume in patients with (n = 14) and without rest tremor (n = 10). Results : Grey matter volume is decreased in the right quadrangular lobe and declive of the cerebellum in PD with tremor compared to those without (PFDR < 0.05). Conclusions : These results demonstrate for the first time morphological changes in the cerebellum in PD patients with rest tremor and highlight the involvement of the cerebellum and cerebello- thalamo-cortical circuit in the pathogenesis of parkinsonian rest tremor