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Role of Lymphatic Vessels in Tumor Immunity: Passive Conduits or Active Participants?

Lund, Amanda ; Swartz, Melody

In: Journal of Mammary Gland Biology and Neoplasia, 2010, vol. 15, no. 3, p. 341-352

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    Titre
    • Role of Lymphatic Vessels in Tumor Immunity: Passive Conduits or Active Participants?
    Auteur
    • Lund, Amanda. Institute of Bioengineering and Swiss Institute of Experimental Cancer Research (ISREC), École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland
    • Swartz, Melody. Institute of Bioengineering and Swiss Institute of Experimental Cancer Research (ISREC), École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Mammary Gland Biology and Neoplasia, 2010, vol. 15, no. 3, p. 341-352. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:320171
    Summary
    Research in lymphatic biology and cancer immunology may soon intersect as emerging evidence implicates the lymphatics in the progression of chronic inflammation and autoimmunity as well as in tumor metastasis and immune escape. Like the blood vasculature, the lymphatic system comprises a highly dynamic conduit system that regulates fluid homeostasis, antigen transport and immune cell trafficking, which all play important roles in the progression and resolution of inflammation, autoimmune diseases, and cancer. This review presents emerging evidence that lymphatic vessels are active modulators of immunity, perhaps fine-tuning the response to adjust the balance between peripheral tolerance and immunity. This suggests that the tumor-associated lymphatic vessels and draining lymph node may be important in tumor immunity which in turn governs metastasis