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Follow-up of women with breast cancer: comparison between MRI and FDG PET

Goerres, Gerhard ; Michel, Sven ; Fehr, Mathias ; Kaim, Achim ; Steinert, Hans ; Seifert, Burkhardt ; von Schulthess, Gustav ; Kubik-Huch, Rahel

In: European Radiology, 2003, vol. 13, no. 7, p. 1635-1644

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    Titre
    • Follow-up of women with breast cancer: comparison between MRI and FDG PET
    Auteur
    • Goerres, Gerhard. Division of Nuclear Medicine, University Hospital, Raemistrasse 100, 8091 Zurich, Switzerland, Switzerland
    • Michel, Sven. Institute of Diagnostic Radiology, Department of Medical Radiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland, Switzerland
    • Fehr, Mathias. Department of Gynaecology and Obstetrics, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland, Switzerland
    • Kaim, Achim. Division of Nuclear Medicine, University Hospital, Raemistrasse 100, 8091 Zurich, Switzerland, Switzerland
    • Steinert, Hans. Division of Nuclear Medicine, University Hospital, Raemistrasse 100, 8091 Zurich, Switzerland, Switzerland
    • Seifert, Burkhardt. Department of Biostatistics, University of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland, Switzerland
    • von Schulthess, Gustav. Division of Nuclear Medicine, University Hospital, Raemistrasse 100, 8091 Zurich, Switzerland, Switzerland
    • Kubik-Huch, Rahel. Institute of Diagnostic Radiology, Department of Medical Radiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Radiology, 2003, vol. 13, no. 7, p. 1635-1644. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:320103
    Summary
    Abstract.: The aim of this study was to compare MRI of the breast with 18F-fluoro-deoxy-glucose (FDG) positron emission tomography (PET) in patients with suspected local or regional breast cancer recurrence or suspected contralateral breast cancer. Thirty-two patients (mean age 57.2years, age range 32-76years) with suspected loco-regional recurrence (n=19), chest wall recurrence (n=5), and suspected secondary tumor of the contralateral breast (n=8) underwent MRI of the breast and FDG PET of the whole body and breast region. Cytology/histology (n=17) or a clinical follow-up examination (n=15) with additional imaging served as the standard of reference. A McNemar test was performed to compare PET and MRI, and kappa was determined to quantify agreement of both methods. Sensitivity was 79 and 100%, specificity was 94 and 72%, and accuracy was 88 and 84% for MRI and PET, respectively. Additional metastases outside the field of view of MRI were found in PET in 5 patients. In this study both imaging methods had comparable accuracy. The detection of distant metastases with whole-body PET imaging can influence patient management